FMO3 Inhibitors
FMO3 inhibitors are chemical compounds that target the FMO3 (Flavin-containing monooxygenase 3) enzyme. FMO3 is a member of the flavin-containing monooxygenase family of enzymes, primarily found in the liver and other tissues, and it plays a significant role in xenobiotic metabolism and the detoxification of various exogenous compounds. FMO3 catalyzes the oxygenation of nucleophilic sulfur, nitrogen, and phosphorus centers present in a wide range of substrates, including dietary amines and pharmaceutical drugs, rendering them more hydrophilic and facilitating their excretion from the body.
Inhibitors of FMO3 modulate the enzyme's activity, potentially interfering with its ability to metabolize specific compounds. These inhibitors may operate through various mechanisms, such as binding to FMO3's active site, disrupting its cofactor-binding sites, or altering its conformation. By inhibiting FMO3, these compounds can impact the metabolism and disposition of various xenobiotics, potentially influencing their bioavailability, toxicity, and elimination kinetics. Research on FMO3 inhibitors is primarily centered around understanding the role of this enzyme in xenobiotic metabolism and exploring its implications for drug interactions and toxicology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $70.00 $112.00 | 4 | |
Acts as a substrate and inhibitor for FMO3 and may lead to decreased FMO3 activity via competitive inhibition or potential downregulation. | ||||||
1-Aminobenzotriazole | 1614-12-6 | sc-200600 sc-200600A | 50 mg 100 mg | $61.00 $134.00 | 6 | |
Known as a nonspecific mechanism-based inhibitor of cytochrome P450 enzymes, potentially affecting FMO3 expression by altering hepatic enzyme balance. | ||||||
Tranylcypromine | 13492-01-8 | sc-200572 sc-200572A | 1 g 5 g | $175.00 $599.00 | 5 | |
An irreversible inhibitor of monoamine oxidase; it could also affect FMO3 expression through secondary effects on hepatic metabolism regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that influences various signaling pathways and may modulate the expression of enzymes like FMO3 through epigenetic effects. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Modifies estrogen metabolism and affects various liver enzymes, potentially leading to altered FMO3 expression. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
An antifungal compound that inhibits cytochrome P450 enzymes, it could indirectly affect FMO3 expression through changes in hepatic metabolism. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
A broad cytochrome P450 enzyme inhibitor, which can potentially alter the expression of other hepatic enzymes like FMO3. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Has been shown to affect the expression of various detoxifying enzymes and may influence FMO3 expression through antioxidant response pathways. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
An alkaloid that can modify enzymes and may affect FMO3 expression by altering hepatic enzyme regulation. | ||||||
Hesperidin | 520-26-3 | sc-205711 sc-205711A | 25 g 100 g | $82.00 $204.00 | 5 | |
A flavonoid glycoside affecting blood lipid levels and metabolism, potentially altering liver enzyme expression, including FMO3. | ||||||