FKBP2 Antibody (D-9): sc-390753
- FKBP2 Antibody (D-9) is a mouse monoclonal IgG1 κ FKBP2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 79-142 mapping at the C-terminus of FKBP2 of human origin
- FKBP2 Antibody (D-9) is recommended for detection of FKBP2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-FKBP2 Antibody (D-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FKBP2 Antibody (D-9) for WB and IHC(P) applications. These reagents are now offered in bundles with FKBP2 Antibody (D-9) (see ordering information below).
FKBP2 Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects FKBP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-FKBP2 antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FKBP2, also known as FK506-binding protein 2 or PPIase (Peptidyl-prolyl cis-trans isomerase), is a 142 amino acid enzyme that plays a crucial role in protein folding by catalyzing the cis-trans isomerization of imidic peptide bonds in oligopeptides. This enzymatic function is vital for proper folding and functioning of proteins, which is essential for cellular homeostasis and response to stress. FKBP2 is predominantly localized to the endoplasmic reticular membrane and is highly expressed in the thymus and T-cells, where FKBP2 acts as an immunophilin, serving as an intracellular receptor that is inhibited by immunosuppressant drugs such as FK506 and rapamycin. Additionally, FKBP2 interacts with specific proteins, including BIG1, a guanine nucleotide exchange factor, and the C-terminus of 4.1G, a protein that stabilizes spectrin-actin binding, highlighting its importance in cellular signaling and structural integrity. The gene encoding FKBP2 is located on human chromosome 11, which is associated with various genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome, underscoring the significance of FKBP2 in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FKBP2 Antibody (D-9) References:
- Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. | Padilla, PI., et al. 2003. Proc Natl Acad Sci U S A. 100: 2322-7. PMID: 12606707
- Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. | DiLella, AG., et al. 1992. Biochem Biophys Res Commun. 189: 819-23. PMID: 1281998
- Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. | Jin, YJ., et al. 1991. Proc Natl Acad Sci U S A. 88: 6677-81. PMID: 1713687
- Identification of all FK506-binding proteins from Neurospora crassa. | Pinto, D., et al. 2008. Fungal Genet Biol. 45: 1600-7. PMID: 18948221
- Exclusion of the 13-kDa rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1. | Grimmond, S., et al. 1995. Hum Genet. 95: 455-8. PMID: 7535744
- Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1). | Courseaux, A., et al. 1996. Genomics. 37: 354-65. PMID: 8938448
- Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. | Lemmens, I., et al. 1997. Genomics. 44: 94-100. PMID: 9286704
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FKBP2 Antibody (D-9) | sc-390753 | 200 µg/ml | $322.00 | |||
FKBP2 Antibody (D-9): m-IgG Fc BP-HRP Bundle | sc-530249 | 200 µg Ab; 10 µg BP | $361.00 | |||
FKBP2 Antibody (D-9): m-IgGκ BP-HRP Bundle | sc-523666 | 200 µg Ab, 40 µg BP | $361.00 | |||
FKBP2 Antibody (D-9): m-IgG1 BP-HRP Bundle | sc-543956 | 200 µg Ab; 20 µg BP | $361.00 | |||
FKBP2 Antibody (D-9) AC | sc-390753 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FKBP2 Antibody (D-9) HRP | sc-390753 HRP | 200 µg/ml | $322.00 | |||
FKBP2 Antibody (D-9) FITC | sc-390753 FITC | 200 µg/ml | $336.00 | |||
FKBP2 Antibody (D-9) PE | sc-390753 PE | 200 µg/ml | $349.00 | |||
FKBP2 Antibody (D-9) Alexa Fluor® 488 | sc-390753 AF488 | 200 µg/ml | $364.00 | |||
FKBP2 Antibody (D-9) Alexa Fluor® 546 | sc-390753 AF546 | 200 µg/ml | $364.00 | |||
FKBP2 Antibody (D-9) Alexa Fluor® 594 | sc-390753 AF594 | 200 µg/ml | $364.00 | |||
FKBP2 Antibody (D-9) Alexa Fluor® 647 | sc-390753 AF647 | 200 µg/ml | $364.00 | |||
FKBP2 Antibody (D-9) Alexa Fluor® 680 | sc-390753 AF680 | 200 µg/ml | $364.00 | |||
FKBP2 Antibody (D-9) Alexa Fluor® 790 | sc-390753 AF790 | 200 µg/ml | $364.00 |