FKBP12 Antibody (8): sc-135908
- FKBP12 Antibody (8) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1-108 representing full length FKBP12 of human origin
- recommended for detection of FKBP12 of mouse, rat, human and canine origin by WB, IP and IF; not recommended for IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FKBP12 Antibody (8). This work is in progress.
FKBP12 Antibody (8) is a mouse monoclonal IgG1 antibody that detects FKBP12 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). FKBP12 is a highly conserved cytoplasmic protein that plays a crucial role in various cellular processes, including T cell activation, cell cycle entry, and intracellular calcium release, making FKBP12 essential for maintaining cellular homeostasis and immune responses. Notably, FKBP12 has been identified as a key regulator that interacts with the intracellular cytoplasmic domain of the type I TGFβ receptor, a relationship that is constitutive and independent of receptor activation. This interaction highlights FKBP12′s potential role in modulating TGFβ signaling pathways, which are critical for numerous physiological processes, including cell growth, differentiation, and apoptosis. FKBP12′s ability to mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506, and Rapamycin further underscores FKBP12′s importance in therapeutic contexts, particularly in transplant biology and autoimmune diseases. With broad species reactivity and versatile applications, anti-FKBP12 antibody (8) serves as an invaluable tool for researchers investigating the multifaceted roles of FKBP12 in cellular signaling and immune regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FKBP12 Antibody (8) | sc-135908 | 50 µg/0.5 ml | $316.00 |