Fibulin-1 Antibody (C11): sc-517435

Fibulin-1 Antibody (C11) is a mouse monoclonal IgG2b kappa light chain antibody that detects Fibulin-1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Fibulin-1 Antibody (C11) is available in a non-conjugated form, allowing for versatile use in various experimental setups. Fibulin-1 is a crucial modular glycoprotein that plays a significant role in the structure and function of the extracellular matrix, particularly in elastic fibers, basement membranes, and blood vessels. Fibulin-1′s ability to self-associate and bind to other key proteins, such as calcium, fibronectin, laminin, nidogen, and fibrinogen, underscores Fibulin-1′s importance in maintaining tissue integrity and facilitating cellular interactions. Fibulin-1′s interactions with these proteins are essential for the stability of the extracellular matrix, which is vital for proper tissue function and repair. Fibulin-1 expression is notably influenced by estrogen in ovarian cancer cell lines, suggesting a dual role as a potential agent of metastasis and a biomarker for assessing cancer risk and aggressiveness in ovarian carcinomas. Research indicates that increased exposure to Fibulin-1 may inhibit cancer cell motility, highlighting Fibulin-1′s complex role in cancer biology. While Fibulin-1′s precise function within the cell remains to be fully elucidated, Fibulin-1′s multifaceted interactions and regulatory mechanisms make this protein of significant interest in both developmental biology and cancer research.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Fibulin-1 Antibody (C11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Fibulin-1 Antibody (C11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Fibulin-1 Antibody (C11) Specifications

Alternate Product Name: Fibulin-1

Product Clone Name: C11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 399-578

Epitope Target: Fibulin-1

Epitope Species: mouse

Product Reactivity/Detection: Fibulin-1

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Fibulin-1 Antibody (C11): N/A

The preferred Fibulin-1 antibody is Fibulin-1 Antibody (B-5): sc-25281.