Fibromodulin Antibody (A-6): sc-166466

Fibromodulin Antibody (A-6) is a mouse monoclonal IgG3 antibody that detects Fibromodulin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fibromodulin is a crucial member of the small leucine-rich proteoglycans (SLRPs) family, which plays a significant role in the organization of the extracellular matrix and interacts with transforming growth factor beta (TGFbeta). Fibromodulin is primarily located in the extracellular matrix of connective tissues, including articular cartilage, tendons, and ligaments, where Fibromodulin is essential for maintaining tissue integrity and function. Fibromodulin influences collagen fibril spacing and thickness in these locations, thereby impacting the mechanical properties of the tissue. The human Fibromodulin gene, located on chromosome 1q32, encodes a 376 amino acid protein characterized by a central region of leucine-rich repeats flanked by disulfide-linked terminal domains. Anti-Fibromodulin antibody (A-6) enables researchers to gain insights into Fibromodulin′s role in various physiological and pathological processes, enhancing our understanding of connective tissue disorders and potential therapeutic targets.

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Fibromodulin Antibody (A-6) References:

1. Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma.  |  Mikaelsson, E., et al. 2005. Blood. 105: 4828-35. PMID: 15741214
2. Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment.  |  Adini, I., et al. 2014. J Clin Invest. 124: 425-36. PMID: 24355922
3. Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.  |  Shami, A., et al. 2015. Atherosclerosis. 241: 701-8. PMID: 26125412
4. The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.  |  Andenæs, K., et al. 2018. PLoS One. 13: e0201422. PMID: 30052659
5. Fibromodulin: Structure, Physiological Functions, and an Emphasis on its Potential Clinical Applications in Various Diseases.  |  Al-Qattan, MM. and Al-Qattan, AM. 2018. J Coll Physicians Surg Pak. 28: 783-790. PMID: 30266125
6. Fibromodulin Gene Variants (FMOD) as Potential Biomarkers for Prostate Cancer and Benign Prostatic Hyperplasia.  |  Silva, T., et al. 2022. Dis Markers. 2022: 5215247. PMID: 35686032
7. Coupled fibromodulin and SOX2 signaling as a critical regulator of metastatic outgrowth in melanoma.  |  Oria, VO., et al. 2022. Cell Mol Life Sci. 79: 377. PMID: 35737114
8. A novel injectable fibromodulin-releasing granular hydrogel for tendon healing and functional recovery.  |  Xu, X., et al. 2023. Bioeng Transl Med. 8: e10355. PMID: 36684085
9. Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway.  |  Liang, Y., et al. 2023. Immun Inflamm Dis. 11: e1003. PMID: 37904680
10. Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway.  |  Wang, K., et al. 2024. Biomater Sci. 12: 1898-1913. PMID: 38426394

The preferred Lumican antibody is Lumican Antibody (B-9): sc-166871.