Fibrinogen α Antibody (UC45): sc-53284
- Fibrinogen α Antibody (UC45) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against acute monoblastic leukemia cells of human origin
- recommended for detection of Fibrinogen α of human origin by IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fibrinogen α Antibody (UC45). This work is in progress.
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Fibrinogen α Antibody (UC45) is a mouse monoclonal IgM antibody that detects Fibrinogen α in human samples through immunofluorescence (IF) applications. Fibrinogen α is one of the three subunits of the plasma glycoprotein Fibrinogen, which plays a crucial role in the coagulation cascade, particularly in the formation of Fibrin, the primary component of blood clots. Fibrinogen α is synthesized in the liver and is essential for platelet aggregation, which is vital for hemostasis following tissue injury. Upon vascular damage, Fibrinogen α is cleaved by Thrombin, resulting in the formation of Fibrin, which not only serves as a scaffold for clot formation but also regulates cell adhesion and spreading. The cleavage products of Fibrinogen α exhibit vasoconstrictor and chemotactic properties, making Fibrinogen α important in the inflammatory response and tissue repair processes. Fibrinogen α is both constitutively expressed and can be induced during acute phase reactions, highlighting Fibrinogen α′s significance in various physiological and pathological conditions. Anti-Fibrinogen α antibody (UC45) is an invaluable tool for researchers studying coagulation processes, vascular biology, and related diseases.
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Fibrinogen α Antibody (UC45) References:
- Fibrinogen alpha C domains contain cryptic plasminogen and tPA binding sites. | Tsurupa, G. and Medved, L. 2001. Ann N Y Acad Sci. 936: 328-30. PMID: 11460488
- Roles of serum fibrinogen α chain-derived peptides in Alzheimer's disease. | Noguchi, M., et al. 2014. Int J Geriatr Psychiatry. 29: 808-18. PMID: 24190360
- Fibrinogen alpha chain is up-regulated and affects the pathogenesis of endometriosis. | Chen, Y., et al. 2019. Reprod Biomed Online. 39: 893-904. PMID: 31740226
- Fibrinogen Alpha Chain Knockout Promotes Tumor Growth and Metastasis through Integrin-AKT Signaling Pathway in Lung Cancer. | Wang, M., et al. 2020. Mol Cancer Res. 18: 943-954. PMID: 32205365
- New visceral manifestations of fibrinogen alpha-chain amyloidosis. | Lionet, A., et al. 2020. Amyloid. 27: 281-282. PMID: 32578461
- A Fibrinogen Alpha Fragment Mitigates Chemotherapy-Induced MLL Rearrangements. | Eberle, J., et al. 2021. Front Oncol. 11: 689063. PMID: 34222016
- Macular Edema in Central Retinal Vein Occlusion Correlates With Aqueous Fibrinogen Alpha Chain. | Cehofski, LJ., et al. 2023. Invest Ophthalmol Vis Sci. 64: 23. PMID: 36820679
- Differential Expression of Fibrinogen Alpha and Its Potential Involvement in Osteoarthritis Pathogenesis. | Kumavat, R., et al. 2025. Mol Biotechnol. 67: 104-114. PMID: 38182865
- Variants leading to dysfibrinogenaemia in the fibrinogen α-chain at residue Arg19 are not solely associated with bleeding, but also with thrombotic events. | Bor, MV. 2024. Br J Haematol. 204: 2501-2503. PMID: 38607667
- Variants leading to dysfibrinogenaemia in the fibrinogen α-chain at residue Arg19 are not solely associated with bleeding, but also with thrombotic events-RESPONSE. | Ramanan, R., et al. 2024. Br J Haematol. 204: 2504. PMID: 38607668
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fibrinogen α Antibody (UC45) | sc-53284 | 200 µg/ml | $322.00 |