Fibrinogen α Antibody (C-7): sc-398806

Fibrinogen α Antibody (C-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects Fibrinogen alpha (FGA) protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FGA antibody (C-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FGA, a key plasma glycoprotein synthesized in the liver, plays a crucial role in the coagulation cascade, particularly in fibrin formation, which is essential for blood clotting and wound healing. Structurally, Fibrinogen consists of three distinct subunits: α, β, and γ, which assemble into a fibrinogen molecule that can be cleaved by thrombin to form fibrin. This structural arrangement enables rapid formation of a stable clot in response to vascular injury, preventing excessive blood loss. FGA cleavage products not only contribute to clot formation but also regulate cell adhesion and migration, display vasoconstrictor and chemotactic properties, and act as mitogens for various cell types, highlighting FGA′s multifaceted role in hemostasis and tissue repair.

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Fibrinogen α Antibody (C-7) References:

1. Curative hepatorenal transplantation in systemic amyloidosis caused by the Glu526Val fibrinogen alpha-chain variant in an English family.  |  Gillmore, JD., et al. 2000. QJM. 93: 269-75. PMID: 10825402
2. Blood rheology, cardiovascular risk factors, and cardiovascular disease: the West of Scotland Coronary Prevention Study.  |  Lowe, G., et al. 2000. Thromb Haemost. 84: 553-8. PMID: 11057849
3. Fibrinogen--marker or mediator of vascular disease?  |  Reinhart, WH. 2003. Vasc Med. 8: 211-6. PMID: 14989564
4. The coagulation cascade: initiation, maintenance, and regulation.  |  Davie, EW., et al. 1991. Biochemistry. 30: 10363-70. PMID: 1931959
5. Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies.  |  Nowak-Göttl, U., et al. 2009. Blood. 114: 1947-53. PMID: 19515723
6. Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene.  |  Chen, Z., et al. 2010. Hum Genet. 128: 443-52. PMID: 20677013
7. Development of a sandwich ELISA for the 5.9-kDa fibrinogen alpha C chain fragment detected by serum proteome analysis.  |  Noda, K., et al. 2011. Proteomics Clin Appl. 5: 141-6. PMID: 21360827
8. Basic mechanisms in blood coagulation.  |  Davie, EW. and Fujikawa, K. 1975. Annu Rev Biochem. 44: 799-829. PMID: 237463
9. miR-451 deficiency is associated with altered endometrial fibrinogen alpha chain expression and reduced endometriotic implant establishment in an experimental mouse model.  |  Nothnick, WB., et al. 2014. PLoS One. 9: e100336. PMID: 24937656
10. Leptospira Immunoglobulin-Like Protein B (LigB) Binds to Both the C-Terminal 23 Amino Acids of Fibrinogen αC Domain and Factor XIII: Insight into the Mechanism of LigB-Mediated Blockage of Fibrinogen α Chain Cross-Linking.  |  Hsieh, CL., et al. 2016. PLoS Negl Trop Dis. 10: e0004974. PMID: 27622634
11. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies.  |  Danesh, J., et al. 1998. JAMA. 279: 1477-82. PMID: 9600484

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Fibrinogen α Antibody (C-7) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-Fibrinogen α Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Fibrinogen α Antibody (C-7) Specifications

Alternate Product Name: Fibrinogen α

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 581-607

Epitope Target: Fibrinogen α

Epitope Species: human

Product Reactivity/Detection: Fibrinogen isoforms α and α-E

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for Fibrinogen α Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin