Fibrinogen α Antibody (A-6): sc-166968

Fibrinogen α Antibody (A-6) is a mouse monoclonal IgG2a antibody that detects Fibrinogen α in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fibrinogen α is one of the three subunits of the plasma glycoprotein Fibrinogen, which plays a crucial role in the coagulation cascade, particularly in the formation of Fibrin, the primary component of blood clots. Fibrinogen α is synthesized in the liver and is essential for platelet aggregation, which is vital for hemostasis following tissue injury. Upon vascular damage, Fibrinogen α is cleaved by Thrombin, resulting in Fibrin formation, which not only serves as a scaffold for clot formation but also regulates cell adhesion and spreading. The cleavage products of Fibrinogen α exhibit vasoconstrictor and chemotactic properties, and act as mitogens for various cell types, highlighting Fibrinogen α′s importance in both coagulation and cellular responses to injury. Fibrinogen α is constitutively expressed and can be induced during acute phase reactions, making Fibrinogen α a significant marker for various pathological conditions.

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Fibrinogen α Antibody (A-6) References:

1. Elevated levels of phosphorylated fibrinogen-alpha-isoforms and differential expression of other post-translationally modified proteins in the plasma of ovarian cancer patients.  |  Ogata, Y., et al. 2006. J Proteome Res. 5: 3318-25. PMID: 17137333
2. Hypodysfibrinogenaemia due to production of mutant fibrinogen alpha-chains lacking fibrinopeptide A and polymerisation knob 'A'.  |  Vorjohann, S., et al. 2010. Thromb Haemost. 104: 990-7. PMID: 20806111
3. Analysis of fibrinogen alpha residues 27-50: interactions with thrombin.  |  Lord, ST. and Binnie, CG. 1990. Blood Coagul Fibrinolysis. 1: 461-3. PMID: 2133223
4. The activation peptide cleft exposed by thrombin cleavage of FXIII-A(2) contains a recognition site for the fibrinogen α chain.  |  Smith, KA., et al. 2013. Blood. 121: 2117-26. PMID: 23303819
5. Fibrinogen geneva II: a new congenitally abnormal fibrinogen alpha chain (Gly17Asp) with a review of similar mutations resulting in abnormal knob A.  |  Casini, A., et al. 2014. Blood Coagul Fibrinolysis. 25: 280-2. PMID: 24389539
6. Fibrinogen alpha chain precursor and apolipoprotein A-I in urine as biomarkers for noninvasive diagnosis of calcium oxalate nephrolithiasis: a proteomics study.  |  Zhu, W., et al. 2014. Biomed Res Int. 2014: 415651. PMID: 25147800
7. Fibrinogen alpha and beta gene polymorphisms in pediatric stroke--case-control and family based study.  |  Kopyta, I., et al. 2015. Eur J Paediatr Neurol. 19: 176-80. PMID: 25555432
8. Fibrinogen alpha C chain 5.9 kDa fragment (FIC5.9), a biomarker for various pathological conditions, is produced in post-blood collection by fibrinolysis and coagulation factors.  |  Kikuchi, W., et al. 2016. Clin Proteomics. 13: 27. PMID: 27761105
9. Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3.  |  Damgaard, D., et al. 2018. PLoS One. 13: e0203214. PMID: 30161253
10. Fibrinogen alpha genes: conservation of bipartite transcripts and carboxy-terminal-extended alpha subunits in vertebrates.  |  Fu, Y., et al. 1995. Genomics. 30: 71-6. PMID: 8595905

The preferred Fibrinogen α antibody is Fibrinogen α Antibody (C-7): sc-398806.