FHL-2 Antibody (F4B2-B11): sc-52667
- FHL-2 Antibody (F4B2-B11) is a mouse monoclonal IgG1, cited in 5 publications, provided at 100 µg/ml
- raised against FHL-2 of human origin
- recommended for detection of FHL-2 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FHL-2 Antibody (F4B2-B11). This work is in progress.
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FHL-2 Antibody (F4B2-B11) is a mouse monoclonal IgG1 antibody that detects FHL-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. FHL-2 plays a crucial role in muscle development and function, as FHL-2 is involved in the regulation of gene expression through interaction with transcription factors like CREB and CREM. FHL-2 is predominantly expressed in cardiac and skeletal muscle, as well as in placenta and ovarian tissues, highlighting FHL-2′s importance in both muscle physiology and reproductive biology. The localization of FHL-2 in the cytosol of myoblasts and myotubes is significant, as such positioning suggests a role in the early stages of muscle differentiation and development. FHL-2′s ability to interact with other FHL proteins allows for the formation of specific protein complexes that can modulate various signaling pathways, further emphasizing FHL-2′s importance in cellular processes. The FHL family of proteins, including FHL-2, exhibits considerable genetic diversity despite similar amino acid sequences, which may contribute to distinct functional roles in different tissues.
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FHL-2 Antibody (F4B2-B11) References:
- Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis. | Wang, J., et al. 2007. Gastroenterology. 132: 1066-76. PMID: 17383428
- The FHL2 regulation in the transcriptional circuitry of human cancers. | Cao, CY., et al. 2015. Gene. 572: 1-7. PMID: 26211626
- FHL2: a scaffold protein of carcinogenesis, tumour-stroma interactions and treatment response. | Verset, L., et al. 2016. Histol Histopathol. 31: 469-78. PMID: 26676939
- Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome. | Zhou, R., et al. 2020. EBioMedicine. 52: 102635. PMID: 32028069
- Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes. | Habibe, JJ., et al. 2022. Diabetologia. 65: 1721-1733. PMID: 35802167
- FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells. | Wang, C., et al. 2023. Cell Death Dis. 14: 239. PMID: 37015904
- FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3. | Xu, Z., et al. 2023. Int J Mol Sci. 25: PMID: 38203523
- Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere. | Li, C., et al. 2024. J Biol Chem. 300: 107254. PMID: 38569934
- Proximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury. | Wang, Y., et al. 2024. Cell Mol Life Sci. 81: 244. PMID: 38814462
- FHL2 expression by cancer-associated fibroblasts promotes metastasis and angiogenesis in lung adenocarcinoma. | Kanzaki, R., et al. 2025. Int J Cancer. 156: 431-446. PMID: 39244734
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FHL-2 Antibody (F4B2-B11) | sc-52667 | 100 µg/ml | $322.00 |