FGF-21 Antibody (Y-16): sc-81946

FGF-21 Antibody (Y-16) is a mouse monoclonal IgG1 kappa light chain antibody that detects FGF-21 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FGF-21 antibody (Y-16) is available as a non-conjugated format. FGF-21 protein plays a crucial role in metabolic regulation, particularly in glucose and lipid metabolism, making FGF-21 an important target for research in metabolic disorders such as obesity and diabetes. FGF-21 is primarily secreted by the liver and adipose tissue, and FGF-21 expression is induced under conditions of stress, such as fasting or cold exposure. FGF-21 acts on various tissues, including the liver, muscle, and adipose tissue, to promote energy expenditure and improve insulin sensitivity. Understanding FGF-21 function and regulation is vital for developing therapeutic strategies aimed at treating metabolic diseases, as FGF-21 has been shown to influence weight loss and improve metabolic health.

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FGF-21 Antibody (Y-16) References:

1. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.  |  Tanaka, A., et al. 1992. Proc Natl Acad Sci U S A. 89: 8928-32. PMID: 1409588
2. FGF-21 as a novel metabolic regulator.  |  Kharitonenkov, A., et al. 2005. J Clin Invest. 115: 1627-35. PMID: 15902306
3. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.  |  Dionne, CA., et al. 1990. EMBO J. 9: 2685-92. PMID: 1697263
4. Forever (FGF) 21.  |  Bass, J. 2013. Nat Med. 19: 1090-2. PMID: 24013744
5. Recent developments in the cell biology of basic fibroblast growth factor.  |  Rifkin, DB. and Moscatelli, D. 1989. J Cell Biol. 109: 1-6. PMID: 2545723
6. Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.  |  Marics, I., et al. 1989. Oncogene. 4: 335-40. PMID: 2649847
7. An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family.  |  Delli Bovi, P., et al. 1987. Cell. 50: 729-37. PMID: 2957062
8. Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.  |  Moore, R., et al. 1986. EMBO J. 5: 919-24. PMID: 3013624
9. Fibroblast growth factor 21 controls mitophagy and muscle mass.  |  Oost, LJ., et al. 2019. J Cachexia Sarcopenia Muscle. 10: 630-642. PMID: 30895728
10. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.  |  Zhan, X., et al. 1988. Mol Cell Biol. 8: 3487-95. PMID: 3211147
11. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.  |  Miyamoto, M., et al. 1993. Mol Cell Biol. 13: 4251-9. PMID: 8321227
12. Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression.  |  Beer, HD., et al. 1997. Oncogene. 15: 2211-8. PMID: 9393979

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGF-21 Antibody (Y-16) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-FGF-21 Antibody (Y-16) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGF-21 Antibody (Y-16) Specifications

Alternate Product Name: FGF-21

Product Clone Name: Y-16

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 30-210

Epitope Target: FGF-21

Epitope Species: human

Product Reactivity/Detection: FGF-21

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for FGF-21 Antibody (Y-16): N/A

The preferred FGF-21 antibody is FGF-21 Antibody (A-4): sc-518101.