FGF-2 Antibody (C-2): sc-74412

FGF-2 Antibody (C-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects fibroblast growth factor-2 (FGF-2) protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FGF-2 antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FGF-2 plays a crucial role in various biological processes, including angiogenesis, wound healing, and tissue repair, by promoting cell proliferation and differentiation. FGF-2 is primarily located in the extracellular matrix and is secreted by various cell types, which is significant because extracellular presence allows interaction with specific receptors on target cells, thereby initiating signaling pathways that lead to cellular responses. FGF-2 interaction with receptors, which are part of a family of receptor tyrosine kinases, is essential for mediating biological effects, making FGF-2 a key player in developmental processes and pathological conditions such as cancer. FGF-2′s ability to stimulate proliferation of mesenchymal, epithelial, and neuroectodermal cells underscores importance in both normal physiology and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FGF-2 Antibody (C-2) References:

1. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.  |  Tanaka, A., et al. 1992. Proc Natl Acad Sci U S A. 89: 8928-32. PMID: 1409588
2. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.  |  Dionne, CA., et al. 1990. EMBO J. 9: 2685-92. PMID: 1697263
3. Recent developments in the cell biology of basic fibroblast growth factor.  |  Rifkin, DB. and Moscatelli, D. 1989. J Cell Biol. 109: 1-6. PMID: 2545723
4. Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.  |  Marics, I., et al. 1989. Oncogene. 4: 335-40. PMID: 2649847
5. An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family.  |  Delli Bovi, P., et al. 1987. Cell. 50: 729-37. PMID: 2957062
6. Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.  |  Moore, R., et al. 1986. EMBO J. 5: 919-24. PMID: 3013624
7. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.  |  Zhan, X., et al. 1988. Mol Cell Biol. 8: 3487-95. PMID: 3211147
8. FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis.  |  Wang, Y., et al. 2022. JCI Insight. 7: PMID: 35439170
9. Fibroblast Growth Factor-2 (FGF-2) Expression in Pterygia Using Cell Spot Arrays.  |  Mastronikolis, S., et al. 2022. Vision (Basel). 6: PMID: 36278670
10. FGF-2 Differentially Regulates Lens Epithelial Cell Behaviour during TGF-β-Induced EMT.  |  Flokis, M. and Lovicu, FJ. 2023. Cells. 12: PMID: 36980168
11. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.  |  Miyamoto, M., et al. 1993. Mol Cell Biol. 13: 4251-9. PMID: 8321227
12. Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression.  |  Beer, HD., et al. 1997. Oncogene. 15: 2211-8. PMID: 9393979

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGF-2 Antibody (C-2) has 37 citations in a variety of scientific publications.

Primary antibodies like Anti-FGF-2 Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGF-2 Antibody (C-2) Specifications

Alternate Product Name: FGF2

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 10-140

Epitope Target: FGF-2

Epitope Species: human

Product Reactivity/Detection: precursor and mature FGF-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: Xenopus

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 37 citations in various scientific publications

Available Conjugates/Forms for FGF-2 Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin