FGD3 Antibody (A-3): sc-390256
- FGD3 Antibody (A-3) is a mouse monoclonal IgG2a κ FGD3 antibody provided at 200 µg/ml
- raised against amino acids 73-173 mapping near the N-terminus of FGD3 of mouse origin
- FGD3 Antibody (A-3) is recommended for detection of FGD3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FGD3 Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FGD3 Antibody (A-3) for WB applications. These reagents are now offered in bundles with FGD3 Antibody (A-3) (see ordering information below).
FGD3 Antibody (A-3) is a mouse monoclonal IgG2b kappa antibody that detects FGD3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FGD3 Antibody (A-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FGD3 protein plays a crucial role in cellular signaling by acting as a guanine nucleotide exchange factor that specifically activates the Rho GTPase Cdc42, which is essential for the regulation of cytoskeletal dynamics and cell morphology. This activation is particularly important for processes such as cell migration, adhesion, and the formation of filopodia, which are actin-rich protrusions that facilitate cellular interactions and signaling. Mutations in the FGD1 gene, which is closely related to FGD3, are associated with faciogenital dysplasia, a developmental disorder that impacts skeletal formation. The FGD family, including FGD3, shares a conserved structural organization and signaling domains, indicating their collective importance in embryonic development and cellular function. Anti-FGD3 antibody (A-3) enables researchers to gain insights into the molecular mechanisms underlying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FGD3 Antibody (A-3) References:
- Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues. | Pasteris, NG. and Gorski, JL. 1999. Genomics. 60: 57-66. PMID: 10458911
- Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue. | Pasteris, NG., et al. 2000. Gene. 242: 237-47. PMID: 10721717
- Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor. | Pasteris, NG., et al. 1994. Cell. 79: 669-78. PMID: 7954831
- The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor. | Zheng, Y., et al. 1996. J Biol Chem. 271: 33169-72. PMID: 8969170
- Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. | Olson, MF., et al. 1996. Curr Biol. 6: 1628-33. PMID: 8994827
- Genomic organization of the faciogenital dysplasia (FGD1; Aarskog syndrome) gene. | Pasteris, NG., et al. 1997. Genomics. 43: 390-4. PMID: 9268645
- CDC42 and FGD1 cause distinct signaling and transforming activities. | Whitehead, IP., et al. 1998. Mol Cell Biol. 18: 4689-97. PMID: 9671479
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FGD3 Antibody (A-3) | sc-390256 | 200 µg/ml | $322.00 | |||
FGD3 Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-530108 | 200 µg Ab; 10 µg BP | $361.00 | |||
FGD3 Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-523467 | 200 µg Ab, 40 µg BP | $361.00 | |||
FGD3 Antibody (A-3) AC | sc-390256 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FGD3 Antibody (A-3) HRP | sc-390256 HRP | 200 µg/ml | $322.00 | |||
FGD3 Antibody (A-3) FITC | sc-390256 FITC | 200 µg/ml | $336.00 | |||
FGD3 Antibody (A-3) PE | sc-390256 PE | 200 µg/ml | $349.00 | |||
FGD3 Antibody (A-3) Alexa Fluor® 488 | sc-390256 AF488 | 200 µg/ml | $364.00 | |||
FGD3 Antibody (A-3) Alexa Fluor® 546 | sc-390256 AF546 | 200 µg/ml | $364.00 | |||
FGD3 Antibody (A-3) Alexa Fluor® 594 | sc-390256 AF594 | 200 µg/ml | $364.00 | |||
FGD3 Antibody (A-3) Alexa Fluor® 647 | sc-390256 AF647 | 200 µg/ml | $364.00 | |||
FGD3 Antibody (A-3) Alexa Fluor® 680 | sc-390256 AF680 | 200 µg/ml | $364.00 | |||
FGD3 Antibody (A-3) Alexa Fluor® 790 | sc-390256 AF790 | 200 µg/ml | $364.00 |