FGD3 Activators
FGD3, or FYVE, RhoGEF, and PH domain-containing protein 3, is a member of the FGD family of proteins that function as guanine nucleotide exchange factors (GEFs) for Rho GTPases, particularly Cdc42. These GTPases are molecular switches that regulate various cellular processes, including changes in the actin cytoskeleton, cell morphology, migration, and division. FGD3 is thus implicated in the intricate regulation of cell shape and movement.The FGD3 protein contains several domains that are critical for its function: a Dbl homology (DH) domain that exhibits the GEF activity, a Pleckstrin homology (PH) domain that can bind phosphoinositides and contribute to membrane association, and a FYVE domain that binds phosphatidylinositol 3-phosphate, often found in membrane trafficking processes.
Mutations in the FGD3 gene have been associated with developmental disorders, highlighting its role in normal growth and development. For instance, it has been linked to Aarskog-Scott syndrome, a disease characterized by skeletal and genital abnormalities, further underscoring its importance in morphogenesis.The expression of FGD3 is regulated by various signaling pathways that respond to extracellular cues, which can influence cell differentiation and tissue development. Due to its involvement in actin cytoskeleton remodeling, FGD3 is also of interest in studies of cell dynamics and diseases where cellular architecture is disrupted.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
It modulates gene expression and might influence the expression of genes involved in cell differentiation, potentially including FGD3. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
It raises cAMP levels, which can affect various signaling pathways and potentially upregulate FGD3 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
As a PKC activator, PMA can modulate signaling pathways that may lead to the upregulation of FGD3. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol found in green tea that may influence gene expression related to cell signaling and cytoskeletal organization. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium affects GSK-3 signaling and Wnt pathway, which might indirectly affect gene expression, including FGD3. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, it can lead to changes in chromatin structure and gene expression, possibly affecting FGD3. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Another histone deacetylase inhibitor that can alter gene expression, potentially affecting FGD3 levels. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog that can permeate cell membranes and may upregulate genes controlled by cAMP-responsive elements, including FGD3. | ||||||
(±)-Methyl Jasmonate | 39924-52-2 | sc-205386 sc-205386A sc-205386B sc-205386C sc-205386D sc-205386E sc-205386F | 1 g 5 g 10 g 50 g 100 g 500 g 1 kg | $36.00 $105.00 $204.00 $890.00 $1671.00 $7081.00 $12491.00 | ||
A plant stress hormone that can also affect mammalian cell signaling and potentially gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound from turmeric that has been shown to affect a variety of signaling pathways and may influence FGD3 expression. | ||||||