FGD1 Antibody (E-10): sc-374389

FGD1 Antibody (E-10) is a mouse monoclonal IgG3 antibody that detects FGD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FGD1 (E-10) antibody is available as the non-conjugated form. FGD1 protein plays a crucial role as a guanine nucleotide exchange factor that specifically activates the Rho GTPase Cdc42, which is essential for various cellular processes, including cell migration, cytoskeletal organization, and the formation of filopodia. These filopodia are vital for cellular signaling and communication during embryonic development, highlighting the importance of FGD1 in developmental biology. Mutations in FGD1 gene are linked to faciogenital dysplasia (FGDY, Aarskog syndrome), an X-linked developmental disorder that negatively impacts the formation of multiple skeletal structures. FGD1 is located on human chromosome Xp11.21 and shares significant sequence identity with FGD2 and FGD3, which are also involved in critical signaling pathways during embryogenesis. The conserved structural organization and equivalent signaling domains among the FGD family members suggest a canonical core structure that is fundamental for their function as Rho guanine nucleotide exchange factors, thereby underscoring their importance in regulating essential signals required for proper embryonic development.

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FGD1 Antibody (E-10) References:

1. Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues.  |  Pasteris, NG. and Gorski, JL. 1999. Genomics. 60: 57-66. PMID: 10458911
2. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes.  |  Hurowitz, EH., et al. 2000. DNA Res. 7: 111-20. PMID: 10819326
3. Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor.  |  Pasteris, NG., et al. 1994. Cell. 79: 669-78. PMID: 7954831
4. The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor.  |  Zheng, Y., et al. 1996. J Biol Chem. 271: 33169-72. PMID: 8969170
5. Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases.  |  Olson, MF., et al. 1996. Curr Biol. 6: 1628-33. PMID: 8994827
6. Genomic organization of the faciogenital dysplasia (FGD1; Aarskog syndrome) gene.  |  Pasteris, NG., et al. 1997. Genomics. 43: 390-4. PMID: 9268645
7. CDC42 and FGD1 cause distinct signaling and transforming activities.  |  Whitehead, IP., et al. 1998. Mol Cell Biol. 18: 4689-97. PMID: 9671479

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGD1 Antibody (E-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FGD1 Antibody (E-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGD1 Antibody (E-10) Specifications

Alternate Product Name: FGD1

Product Clone Name: E-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃

Amino Acids: 71-107

Epitope Target: FGD1

Epitope Species: human

Product Reactivity/Detection: FGD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FGD1 Antibody (E-10): P: Blocking Peptide