FEZF1 Antibody (F-4): sc-515487

FEZF1 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects FEZF1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FEZF1 antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FEZF1, also known as Fez family zinc finger protein 1, plays a crucial role in the development of the olfactory system, particularly in guiding olfactory sensory neuron axons to the olfactory bulb. This process enables accurate transmission of sensory information related to smell. In FEZF1-deficient mice, olfactory axons fail to reach the olfactory bulb, highlighting FEZF1′s importance in facilitating axon penetration through the central nervous system′s basal lamina. FEZF1 functions as a 475 amino acid nuclear protein that, upon nuclear translocation, can induce KRAS overexpression, leading to ERK signaling pathway activation. Such overexpression associates with accelerated cell proliferation and increased tumor mass in experimental models, underscoring FEZF1′s potential implications in cancer biology. Alternative splicing produces three FEZF1 isoforms, contributing to diverse functional roles in cellular processes.

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FEZF1 Antibody (F-4) References:

1. Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos.  |  Matsuo-Takasaki, M., et al. 2000. Mech Dev. 93: 201-4. PMID: 10781957
2. Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously.  |  Hirata, T., et al. 2006. Development. 133: 1433-43. PMID: 16540508
3. Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions.  |  Hirata, T., et al. 2006. Development. 133: 3993-4004. PMID: 16971467
4. The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.  |  Kurrasch, DM., et al. 2007. J Neurosci. 27: 13624-34. PMID: 18077674
5. C2H2 zinc finger genes of the Gli, Zic, KLF, SP, Wilms' tumour, Huckebein, Snail, Ovo, Spalt, Odd, Blimp-1, Fez and related gene families from Branchiostoma floridae.  |  Shimeld, SM. 2008. Dev Genes Evol. 218: 639-49. PMID: 18795322
6. Formation and patterning of the forebrain and olfactory system by zinc-finger genes Fezf1 and Fezf2.  |  Shimizu, T. and Hibi, M. 2009. Dev Growth Differ. 51: 221-31. PMID: 19222525
7. Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene.  |  Song, IS., et al. 2009. Cancer Res. 69: 3131-9. PMID: 19318583
8. Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development.  |  Watanabe, Y., et al. 2009. J Comp Neurol. 515: 565-84. PMID: 19479999
9. FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies.  |  Shi, C., et al. 2019. Biosci Rep. 39: PMID: 31175144
10. Long noncoding RNA FEZF1-AS1 in human cancers.  |  Zhou, Y., et al. 2019. Clin Chim Acta. 497: 20-26. PMID: 31276636
11. [Progress in Role of FEZF1-AS1 in Non-small Cell Lung Cancer].  |  Chen, J., et al. 2020. Zhongguo Fei Ai Za Zhi. 23: 294-298. PMID: 32228826
12. LncRNA FEZF1-AS1 accelerates multiple myeloma progression by regulating IGF2BP1/BZW2 signaling.  |  Long, X., et al. 2023. Hematol Oncol. 41: 694-703. PMID: 37125488

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FEZF1 Antibody (F-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-FEZF1 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FEZF1 Antibody (F-4) Specifications

Alternate Product Name: FEZF1

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 74-262

Epitope Target: FEZF1

Epitope Species: human

Product Reactivity/Detection: FEZF1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for FEZF1 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin