Fes Antibody (E-1): sc-166371
- Fes Antibody (E-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 18-44 near the N-terminus of Fes of human origin
- recommended for detection of Fes of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fes Antibody (E-1). This work is in progress.
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Fes Antibody (E-1) is a mouse monoclonal IgG1 antibody that detects Fes in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Fes antibody (E-1) recognizes Fes, a crucial tyrosine kinase encoded by the proto-oncogene c-fes, which plays a significant role in the regulation of myeloid differentiation, particularly in macrophages. Fes (E-1) antibody targets a protein structure that includes an SH2 domain and undergoes autophosphorylation, essential features for function in signal transduction pathways. These structural features enable Fes to interact with various hematopoietic cytokine receptors and the B cell receptor (BCR), facilitating critical cellular responses. Notably, phosphorylation of BCR by Fes promotes association with the Ras guanine nucleotide exchange factor complex GRB2/Sos, highlighting Fes importance in modulating signaling pathways that influence cell growth and differentiation. Anti-Fes antibody (E-1) versatility in multiple applications makes this reagent an invaluable tool for researchers studying the intricate roles of Fes in cellular processes and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fes Antibody (E-1) References:
- NMR assignment of the SH2 domain from the human feline sarcoma oncogene FES. | Scott, A., et al. 2004. J Biomol NMR. 30: 463-4. PMID: 15630569
- Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes. | Scott, A., et al. 2005. J Biomol NMR. 31: 357-61. PMID: 15929003
- FES kinases are required for oncogenic FLT3 signaling. | Voisset, E., et al. 2010. Leukemia. 24: 721-8. PMID: 20111072
- Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein. | MacDonald, I., et al. 1985. Mol Cell Biol. 5: 2543-51. PMID: 2426571
- Pathological significance and prognostic significance of FES expression in bladder cancer vary according to tumor grade. | Asai, A., et al. 2018. J Cancer Res Clin Oncol. 144: 21-31. PMID: 28952025
- Expression of the human fes cellular oncogene in renal cell tumors. | Karthaus, HF., et al. 1986. Urol Res. 14: 123-7. PMID: 3018974
- The structure of the human c-fes/fps proto-oncogene. | Roebroek, AJ., et al. 1985. EMBO J. 4: 2897-903. PMID: 4065096
- Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. | Groffen, J., et al. 1982. Science. 216: 1136-8. PMID: 6281890
- Chromosomal sublocalization of human c-myb and c-fes cellular onc genes. | Harper, ME., et al. Nature. 304: 169-71. PMID: 6866112
- Malignant transformation of a human fibroblast cell strain by transfection of a v-fes oncogene but not by transfection of a gag-human c-fes construct. | Lin, C., et al. 1994. Cell Growth Differ. 5: 1381-7. PMID: 7696187
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fes Antibody (E-1) | sc-166371 | 200 µg/ml | $316.00 | |||
Fes (E-1) Neutralizing Peptide | sc-166371 P | 100 µg/0.5 ml | $68.00 |