Fes Antibody (5A11G5): sc-81706
- Fes Antibody (5A11G5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 613-822 of Fes of human origin
- recommended for detection of Fes of human origin by WB, IP and IF
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Fes Antibody (5A11G5) for WB applications. This reagent is now offered in a bundle with Fes Antibody (5A11G5) (see ordering information below).
QUICK LINKS
SEE ALSO...
Fes Antibody (5A11G5) is a mouse monoclonal IgG1 antibody that detects Fes in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Fes is a crucial tyrosine kinase encoded by the proto-oncogene c-fes, primarily expressed in macrophages, and plays a significant role in the regulation of myeloid differentiation. Anti-Fes antibody (5A11G5) recognizes several key characteristics typical of cytoplasmic class protein tyrosine kinases, including an SH2 domain and the ability to undergo autophosphorylation, which are essential for its function in signal transduction pathways. Notably, Fes has been shown to interact with interleukin-4 and various hematopoietic cytokine receptors, as well as the B cell receptor (BCR). The phosphorylation of BCR by Fes is particularly important as it facilitates the association of BCR with the Ras guanine nucleotide exchange factor complex GRB2/Sos, thereby influencing downstream signaling events that are critical for immune responses. Fes monoclonal antibody (5A11G5) is an invaluable tool for researchers studying the intricate mechanisms of myeloid differentiation and the signaling pathways involved in immune regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fes Antibody (5A11G5) References:
- Fully automated structure determinations of the Fes SH2 domain using different sets of NMR spectra. | Scott, A., et al. 2006. Magn Reson Chem. 44 Spec No: S83-8. PMID: 16826546
- Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids. | Sundaresan, S. and Francke, U. 1989. Somat Cell Mol Genet. 15: 373-6. PMID: 2548293
- Expression of the human fes cellular oncogene in renal cell tumors. | Karthaus, HF., et al. 1986. Urol Res. 14: 123-7. PMID: 3018974
- Identification of FES as a Novel Radiosensitizing Target in Human Cancers. | Kim, BH., et al. 2020. Clin Cancer Res. 26: 265-273. PMID: 31573955
- Human cellular fps/fes cDNA rescued via retroviral shuttle vector encodes myeloid cell NCP92 and has transforming potential. | Feldman, RA., et al. 1987. Oncogene Res. 1: 441-58. PMID: 3329718
- Structure of the feline c-fes/fps proto-oncogene: genesis of a retroviral oncogene. | Roebroek, AJ., et al. 1987. J Virol. 61: 2009-16. PMID: 3553615
- The structure of the human c-fes/fps proto-oncogene. | Roebroek, AJ., et al. 1985. EMBO J. 4: 2897-903. PMID: 4065096
- Localization of the cellular oncogenes ABL, SIS, and FES on human germ-line chromosomes. | Jhanwar, SC., et al. 1984. Cytogenet Cell Genet. 38: 73-5. PMID: 6323103
- Transforming potential of a human protooncogene (c-fps/fes) locus. | Sodroski, JG., et al. 1984. Proc Natl Acad Sci U S A. 81: 3039-43. PMID: 6328490
- Genetic mapping of the mouse oncogenes c-Ha-ras-1 and c-fes to chromosome 7. | Kozak, CA., et al. 1983. J Virol. 47: 217-20. PMID: 6864883
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fes Antibody (5A11G5) | sc-81706 | 200 µg/ml | $316.00 | |||
Fes Antibody (5A11G5): m-IgG1 BP-HRP Bundle | sc-542629 | 200 µg Ab; 20 µg BP | $354.00 |