Fes Antibody (2E3G3): sc-81704
- Fes Antibody (2E3G3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 613-822 of Fes of human origin
- recommended for detection of Fes of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fes Antibody (2E3G3). This work is in progress.
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Fes Antibody (2E3G3) is a mouse monoclonal IgG1 antibody that detects Fes in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Fes is a crucial tyrosine kinase encoded by the proto-oncogene c-fes, primarily expressed in macrophages, and plays a significant role in the regulation of myeloid differentiation. Fes (2E3G3) antibody recognizes several key structural elements typical of cytoplasmic protein tyrosine kinases, including an SH2 domain that facilitates protein-protein interactions and autophosphorylation capabilities essential for activation and function. Fes associates with interleukin-4 and various hematopoietic cytokine receptors, as well as the B cell receptor (BCR). Notably, BCR phosphorylation by Fes triggers recruitment of the Ras guanine nucleotide exchange factor complex GRB2/Sos, which is vital for downstream signaling pathways influencing cell proliferation and differentiation. Anti-Fes antibody (2E3G3) serves as an invaluable tool for researchers investigating signaling mechanisms in myeloid cells and their implications in immune responses and hematological disorders.
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Fes Antibody (2E3G3) References:
- NMR assignment of the SH2 domain from the human feline sarcoma oncogene FES. | Scott, A., et al. 2004. J Biomol NMR. 30: 463-4. PMID: 15630569
- Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes. | Scott, A., et al. 2005. J Biomol NMR. 31: 357-61. PMID: 15929003
- FES kinases are required for oncogenic FLT3 signaling. | Voisset, E., et al. 2010. Leukemia. 24: 721-8. PMID: 20111072
- Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein. | MacDonald, I., et al. 1985. Mol Cell Biol. 5: 2543-51. PMID: 2426571
- Pathological significance and prognostic significance of FES expression in bladder cancer vary according to tumor grade. | Asai, A., et al. 2018. J Cancer Res Clin Oncol. 144: 21-31. PMID: 28952025
- Identification of FES as a Novel Radiosensitizing Target in Human Cancers. | Kim, BH., et al. 2020. Clin Cancer Res. 26: 265-273. PMID: 31573955
- Structure of the feline c-fes/fps proto-oncogene: genesis of a retroviral oncogene. | Roebroek, AJ., et al. 1987. J Virol. 61: 2009-16. PMID: 3553615
- Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. | Groffen, J., et al. 1982. Science. 216: 1136-8. PMID: 6281890
- Chromosomal sublocalization of human c-myb and c-fes cellular onc genes. | Harper, ME., et al. Nature. 304: 169-71. PMID: 6866112
- Malignant transformation of a human fibroblast cell strain by transfection of a v-fes oncogene but not by transfection of a gag-human c-fes construct. | Lin, C., et al. 1994. Cell Growth Differ. 5: 1381-7. PMID: 7696187
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fes Antibody (2E3G3) | sc-81704 | 200 µg/ml | $316.00 |