ferritin heavy chain Antibody (C6): sc-517438

Ferritin heavy chain Antibody (C6) is a mouse monoclonal IgG2b antibody that detects ferritin heavy chain in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Ferritin heavy chain plays a crucial role in iron metabolism, primarily by catalyzing the oxidation of ferrous iron (FeII) to ferric iron (FeIII), which is essential for safe iron storage within cells. This process prevents the toxic effects of free iron and contributes to overall iron-buffering capacity of cells, ensuring iron availability for vital biological processes such as hemoglobin synthesis and cellular respiration. Additionally, ferritin heavy chain is implicated in thymidine biosynthesis regulation by enhancing cytoplasmic serine hydroxymethyltransferase expression, a key enzyme in thymidylate synthesis critical for DNA replication and repair. Ferritin heavy chain′s ability to modulate iron levels and influence cellular metabolism underscores its importance in maintaining cellular homeostasis and responding to oxidative stress, making anti-ferritin heavy chain antibody (C6) an invaluable tool for researchers studying iron metabolism and related pathologies.

The preferred ferritin heavy chain antibody is ferritin heavy chain Antibody (B-12): sc-376594.