FDX1L Antibody (C-12): sc-515121

FDX1L Antibody (C-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects FDX1L protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FDX1L antibody (C-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FDX1L, an Adrenodoxin-like protein, plays a crucial role in electron transport within mitochondria, facilitating electron transfer from NADPH-dependent adrenodoxin reductase to cytochrome P450 enzymes. This process is vital for steroid hormone biosynthesis, including cortisol and aldosterone, which are essential for regulating metabolism, immune response, and blood pressure. FDX1L is encoded by a gene located on human chromosome 19, a region known for high gene density and association with various genetic disorders. FDX1L′s localization in the adrenal cortex mitochondrial matrix underscores its importance in steroidogenesis, as any dysfunction in this pathway can lead to significant hormonal imbalances and related health issues. Anti-FDX1L antibody (C-12) serves as an invaluable tool for researchers studying adrenal function and related metabolic pathways, providing insights into molecular mechanisms underlying various endocrine disorders.

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FDX1L Antibody (C-12) References:

1. A fine physical map of the CACNA1A gene region on 19p13.1-p13.2 chromosome.  |  Trettel, F., et al. 2000. Gene. 241: 45-50. PMID: 10607897
2. Adrenodoxin: structure, stability, and electron transfer properties.  |  Grinberg, AV., et al. 2000. Proteins. 40: 590-612. PMID: 10899784
3. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).  |  LaPoint, SF., et al. 2000. Adv Anat Pathol. 7: 307-21. PMID: 10976909
4. A new electron transport mechanism in mitochondrial steroid hydroxylase systems based on structural changes upon the reduction of adrenodoxin.  |  Beilke, D., et al. 2002. Biochemistry. 41: 7969-78. PMID: 12069587
5. Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters.  |  Moodie, SJ., et al. 2002. Eur J Immunogenet. 29: 287-91. PMID: 12121272
6. Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2.  |  Buchet-Poyau, K., et al. 2002. Cytogenet Genome Res. 97: 171-8. PMID: 12438709
7. The DNA sequence and biology of human chromosome 19.  |  Grimwood, J., et al. 2004. Nature. 428: 529-35. PMID: 15057824
8. Immunogenetics of killer cell immunoglobulin-like receptors.  |  Parham, P. 2005. Mol Immunol. 42: 459-62. PMID: 15607799
9. BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription.  |  Brocke-Heidrich, K., et al. 2006. Oncogene. 25: 7297-304. PMID: 16732314
10. A novel CADASIL-causing mutation in a stroke patient.  |  Vikelis, M., et al. 2007. Swiss Med Wkly. 137: 323-5. PMID: 17629811
11. Assignment of the functional gene for human adrenodoxin to chromosome 11q13----qter and of adrenodoxin pseudogenes to chromosome 20cen----q13.1.  |  Morel, Y., et al. 1988. Am J Hum Genet. 43: 52-9. PMID: 2837084
12. Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors.  |  Zimmermann, W., et al. 1988. Cancer Res. 48: 2550-4. PMID: 3356015

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FDX1L Antibody (C-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-FDX1L Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FDX1L Antibody (C-12) Specifications

Alternate Product Name: FDX1L

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 48-104

Epitope Target: FDX1L

Epitope Species: human

Product Reactivity/Detection: FDX1L

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for FDX1L Antibody (C-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin