FBXO44 Antibody (C-10): sc-398020
- FBXO44 Antibody (C-10) is a mouse monoclonal IgG1 κ FBXO44 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 86-125 mapping within an internal region of FBXO44 of human origin
- FBXO44 Antibody (C-10) is recommended for detection of FBXO44 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- Anti-FBXO44 Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FBXO44 Antibody (C-10) for WB applications. These reagents are now offered in bundles with FBXO44 Antibody (C-10) (see ordering information below).
FBXO44 Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects FBXO44 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FBXO44 (C-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FBXO44, also known as F-box only protein 44, FBG3, FBX30, FBX44, FBX6A, or FBXO6A, is a 255 amino acid protein characterized by the presence of one F-box domain and one FBA domain, which are crucial for its role in the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex. FBXO44 is primarily expressed in the kidney and brain, with lower expression levels in the liver, heart, and spleen, and exists as multiple alternatively spliced isoforms. FBXO44 plays a significant role in substrate recognition and recruitment for ubiquitination, which is essential for regulating various cellular processes, including the cell cycle, immune responses, signaling pathways, and developmental events. FBXO44′s ability to target specific proteins, such as cyclins and cyclin-dependent kinase inhibitors, for proteasomal degradation underscores its importance in maintaining cellular homeostasis and regulating protein turnover, making FBXO44 a vital component in the intricate network of cellular regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FBXO44 Antibody (C-10) References:
- Identification of a family of human F-box proteins. | Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
- A family of mammalian F-box proteins. | Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
- cDNA cloning and expression analysis of new members of the mammalian F-box protein family. | Ilyin, GP., et al. 2000. Genomics. 67: 40-7. PMID: 10945468
- A new subfamily of structurally related human F-box proteins. | Ilyin, GP., et al. 2002. Gene. 296: 11-20. PMID: 12383498
- The SCF ubiquitin ligase: insights into a molecular machine. | Cardozo, T. and Pagano, M. 2004. Nat Rev Mol Cell Biol. 5: 739-51. PMID: 15340381
- Systematic analysis and nomenclature of mammalian F-box proteins. | Jin, J., et al. 2004. Genes Dev. 18: 2573-80. PMID: 15520277
- Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. | Glenn, KA., et al. 2008. J Biol Chem. 283: 12717-29. PMID: 18203720
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FBXO44 Antibody (C-10) | sc-398020 | 200 µg/ml | $322.00 | |||
FBXO44 Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-530664 | 200 µg Ab; 10 µg BP | $361.00 | |||
FBXO44 Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-524184 | 200 µg Ab, 40 µg BP | $361.00 | |||
FBXO44 Antibody (C-10): m-IgG1 BP-HRP Bundle | sc-544190 | 200 µg Ab; 20 µg BP | $361.00 | |||
FBXO44 Antibody (C-10) AC | sc-398020 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FBXO44 Antibody (C-10) HRP | sc-398020 HRP | 200 µg/ml | $322.00 | |||
FBXO44 Antibody (C-10) FITC | sc-398020 FITC | 200 µg/ml | $336.00 | |||
FBXO44 Antibody (C-10) PE | sc-398020 PE | 200 µg/ml | $349.00 | |||
FBXO44 Antibody (C-10) Alexa Fluor® 488 | sc-398020 AF488 | 200 µg/ml | $364.00 | |||
FBXO44 Antibody (C-10) Alexa Fluor® 546 | sc-398020 AF546 | 200 µg/ml | $364.00 | |||
FBXO44 Antibody (C-10) Alexa Fluor® 594 | sc-398020 AF594 | 200 µg/ml | $364.00 | |||
FBXO44 Antibody (C-10) Alexa Fluor® 647 | sc-398020 AF647 | 200 µg/ml | $364.00 | |||
FBXO44 Antibody (C-10) Alexa Fluor® 680 | sc-398020 AF680 | 200 µg/ml | $364.00 | |||
FBXO44 Antibody (C-10) Alexa Fluor® 790 | sc-398020 AF790 | 200 µg/ml | $364.00 |