FBXO22 Antibody (FF-7): sc-100736

FBXO22 Antibody (FF-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects FBXO22 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FBXO22 antibody (FF-7) is available as a non-conjugated monoclonal isotype antibody. FBXO22, also known as F-box only protein 22 or FBX22p44, is a 403 amino acid protein predominantly expressed in the liver, where FBXO22 plays a crucial role in cellular regulation. As a member of the F-box protein family, FBXO22 is an integral component of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex, which is essential for substrate recognition and recruitment for ubiquitination. This process is vital for the targeted degradation of various proteins, including cyclins and cyclin-dependent kinase inhibitors, which are key regulators of the cell cycle and other critical cellular processes. FBXO22-mediated degradation of these proteins underscores FBXO22′s importance in maintaining cellular homeostasis and regulating the immune response, signaling pathways, and developmental processes. Notably, three isoforms of FBXO22 exist due to alternative splicing, which may contribute to FBXO22′s functional diversity and regulatory roles within different cellular contexts.

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FBXO22 Antibody (FF-7) References:

1. Identification of a family of human F-box proteins.  |  Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
2. A family of mammalian F-box proteins.  |  Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
3. Systematic analysis and nomenclature of mammalian F-box proteins.  |  Jin, J., et al. 2004. Genes Dev. 18: 2573-80. PMID: 15520277
4. Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp).  |  Bernis, C., et al. 2007. EMBO Rep. 8: 91-8. PMID: 17159919
5. The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo.  |  Cooke, PS., et al. 2007. Obesity (Silver Spring). 15: 1400-8. PMID: 17557977
6. F-box proteins that contain sugar-binding domains.  |  Yoshida, Y. 2007. Biosci Biotechnol Biochem. 71: 2623-31. PMID: 17986767

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FBXO22 Antibody (FF-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-FBXO22 Antibody (FF-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FBXO22 Antibody (FF-7) Specifications

Alternate Product Name: FBXO22

Product Clone Name: FF-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: FBXO22

Epitope Species: human

Product Reactivity/Detection: FBXO22

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for FBXO22 Antibody (FF-7): N/A