FBXO11 Antibody (E-9): sc-393229
- FBXO11 Antibody (E-9) is a mouse monoclonal IgG2b κ FBXO11 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 90-109 near the N-terminus of FBXO11 of human origin
- FBXO11 Antibody (E-9) is recommended for detection of FBXO11 of mouse, rat, human and origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- Anti-FBXO11 Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for FBXO11 Antibody (E-9) for WB and IHC(P) applications. These reagents are now offered in bundles with FBXO11 Antibody (E-9) (see ordering information below).
FBXO11 Antibody (E-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects FBXO11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FBXO11 antibody (E-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FBXO11, also known as F-box only protein 11 or VIT1, is a 927 amino acid nuclear protein that plays a crucial role in the ubiquitin-proteasome pathway, functioning as a substrate recognition component of the SCF (Skp1-CUL-1-F-box protein) E3 ubiquitin ligase complex. This complex is essential for the targeted degradation of specific proteins, including cyclins and p53, which are vital for regulating the cell cycle and maintaining genomic stability. FBXO11′s ability to bind and inhibit p53′s transcriptional activity highlights FBXO11′s importance in cellular responses to stress and tumor suppression. Additionally, reduced FBXO11 expression has been linked to vitiligo, a condition characterized by the loss of skin pigmentation, underscoring FBXO11′s potential role in skin health and disease. Multiple FBXO11 isoforms arise from alternative splicing, which may contribute to FBXO11′s diverse functional roles in various cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FBXO11 Antibody (E-9) References:
- Identification of a family of human F-box proteins. | Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
- A family of mammalian F-box proteins. | Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
- 'VIT1', a novel gene associated with vitiligo. | Le Poole, IC., et al. 2001. Pigment Cell Res. 14: 475-84. PMID: 11775060
- Systematic analysis and nomenclature of mammalian F-box proteins. | Jin, J., et al. 2004. Genes Dev. 18: 2573-80. PMID: 15520277
- FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. | Cook, JR., et al. 2006. Biochem Biophys Res Commun. 342: 472-81. PMID: 16487488
- Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study. | Segade, F., et al. 2006. Arch Otolaryngol Head Neck Surg. 132: 729-33. PMID: 16847180
- FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. | Abida, WM., et al. 2007. J Biol Chem. 282: 1797-804. PMID: 17098746
- Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. | Lee, MJ., et al. 2008. Proc Natl Acad Sci U S A. 105: 100-5. PMID: 18162545
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FBXO11 Antibody (E-9) | sc-393229 | 200 µg/ml | $316.00 | |||
FBXO11 Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-526229 | 200 µg Ab; 10 µg BP | $354.00 | |||
FBXO11 Antibody (E-9): m-IgG2b BP-HRP Bundle | sc-549697 | 200 µg Ab; 10 µg BP | $354.00 | |||
FBXO11 Antibody (E-9) AC | sc-393229 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FBXO11 Antibody (E-9) HRP | sc-393229 HRP | 200 µg/ml | $316.00 | |||
FBXO11 Antibody (E-9) FITC | sc-393229 FITC | 200 µg/ml | $330.00 | |||
FBXO11 Antibody (E-9) PE | sc-393229 PE | 200 µg/ml | $343.00 | |||
FBXO11 Antibody (E-9) Alexa Fluor® 488 | sc-393229 AF488 | 200 µg/ml | $357.00 | |||
FBXO11 Antibody (E-9) Alexa Fluor® 546 | sc-393229 AF546 | 200 µg/ml | $357.00 | |||
FBXO11 Antibody (E-9) Alexa Fluor® 594 | sc-393229 AF594 | 200 µg/ml | $357.00 | |||
FBXO11 Antibody (E-9) Alexa Fluor® 647 | sc-393229 AF647 | 200 µg/ml | $357.00 | |||
FBXO11 Antibody (E-9) Alexa Fluor® 680 | sc-393229 AF680 | 200 µg/ml | $357.00 | |||
FBXO11 Antibody (E-9) Alexa Fluor® 790 | sc-393229 AF790 | 200 µg/ml | $357.00 | |||
FBXO11 (E-9) Neutralizing Peptide | sc-393229 P | 100 µg/0.5 ml | $68.00 |