FBP1 Antibody (B-7): sc-374342

FBP1 Antibody (B-7) is a mouse monoclonal IgG1 antibody that detects FBP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FUSE-binding protein 1 (FBP1) plays a crucial role in regulating the expression of the c-Myc gene, which is essential for cell proliferation and growth. FBP1 binds specifically to the far upstream element (FUSE) of the c-Myc gene, acting as a growth-dependent regulator that is vital for maintaining the expression of c-Myc in undifferentiated cells. FBP1′s importance is underscored by its expression pattern; FBP1 is predominantly found in undifferentiated cells, and FBP1 levels significantly decrease upon differentiation, which can impact cellular growth and function. The FBP family, which includes FBP1, FBP2, and FBP3, consists of single-stranded DNA-binding proteins that share a conserved central DNA-binding domain and exhibit significant homology in their carboxyl-terminal activation domains, highlighting their functional similarities and importance in gene regulation. Anti-FBP1 antibody (B-7) is an invaluable tool for researchers studying the mechanisms of gene expression and cellular differentiation.

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FBP1 Antibody (B-7) References:

1. Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression.  |  Cong, J., et al. 2018. Cell Metab. 28: 243-255.e5. PMID: 30033198
2. FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome.  |  Li, F., et al. 2020. Nat Cell Biol. 22: 728-739. PMID: 32367049
3. FBP1-Altered Carbohydrate Metabolism Reduces Leukemic Viability through Activating P53 and Modulating the Mitochondrial Quality Control System In Vitro.  |  Xu, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36232688
4. FBP1 induced by β-elemene enhances the sensitivity of gefitinib in lung cancer.  |  Li, J., et al. 2023. Thorac Cancer. 14: 371-380. PMID: 36525508
5. Hepatic but not Intestinal FBP1 Is Required for Fructose Metabolism and Tolerance.  |  Bai, Q., et al. 2023. Endocrinology. 164: PMID: 36964915
6. AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription.  |  He, X., et al. 2023. Clin Transl Med. 13: e1352. PMID: 37565737
7. The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7.  |  Chen, W., et al. 2024. Cardiovasc Diabetol. 23: 21. PMID: 38195542
8. Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1.  |  Xu, Y., et al. 2024. J Transl Med. 22: 74. PMID: 38238754
9. FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation.  |  He, T., et al. 2024. Cell Mol Life Sci. 81: 87. PMID: 38349431
10. FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation.  |  Zhang, P., et al. 2024. Cell Death Dis. 15: 392. PMID: 38834617

The preferred FBP1 antibody is FBP1 Antibody (G-8): sc-271241.