FBL18 Antibody (LL-3): sc-100738

FBL18 Antibody (LL-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects the FBL18 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-FBL18 antibody (LL-3) is available as the non-conjugated format. FBL18, also known as F-box and leucine-rich repeat protein 18 or FBXL18, is an 805 amino acid protein characterized by the presence of an F-box motif at its N-terminus, followed by multiple leucine-rich repeats and a transmembrane domain at the C-terminus. FBL18 plays a crucial role in the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex, which is essential for the ubiquitination process that regulates protein degradation within the cell. FBL18′s ability to interact with specific proteins, such as SKP1A p19 and CUL-1, highlights its importance in substrate recognition and recruitment, thereby influencing various cellular processes including the cell cycle, immune response, and developmental signaling pathways. Notably, FBL18 undergoes alternative splicing, resulting in four distinct isoforms, which may have different regulatory roles and functional implications in cellular homeostasis and disease states.

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FBL18 Antibody (LL-3) References:

1. Identification of a family of human F-box proteins.  |  Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
2. A family of mammalian F-box proteins.  |  Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
3. Systematic analysis and nomenclature of mammalian F-box proteins.  |  Jin, J., et al. 2004. Genes Dev. 18: 2573-80. PMID: 15520277
4. Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp).  |  Bernis, C., et al. 2007. EMBO Rep. 8: 91-8. PMID: 17159919
5. The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo.  |  Cooke, PS., et al. 2007. Obesity (Silver Spring). 15: 1400-8. PMID: 17557977
6. F-box proteins that contain sugar-binding domains.  |  Yoshida, Y. 2007. Biosci Biotechnol Biochem. 71: 2623-31. PMID: 17986767

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FBL18 Antibody (LL-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FBL18 Antibody (LL-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FBL18 Antibody (LL-3) Specifications

Alternate Product Name: FBL18

Product Clone Name: LL-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-111

Epitope Target: FBL18

Epitope Species: human

Product Reactivity/Detection: FBL18

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FBL18 Antibody (LL-3): N/A