FANCG Antibody (75-A): sc-100740
- FANCG Antibody (75-A) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant FANCG of human origin
- recommended for detection of FANCG of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FANCG Antibody (75-A). This work is in progress.
FANCG Antibody (75-A) is a mouse monoclonal IgG2a antibody that detects FANCG in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FANCG plays a crucial role in the Fanconi anemia (FA) pathway, which is essential for maintaining genomic stability and repairing DNA cross-links. FANCG is primarily localized in the nucleus, where FANCG participates in the repair of damaged DNA, and proper function is vital for preventing chromosomal instability, a hallmark of FA. The regulation of FANCG, particularly through post-translational modifications like phosphorylation, is significant; for instance, the phosphorylation of serine 7 in FANCG is critical for FANCG′s role in the FA pathway. This modification enhances FANCG′s ability to respond to DNA damage, thereby safeguarding cellular integrity. FANCG is highly expressed in the testis and thymus, indicating FANCG′s importance in cellular processes related to these tissues. Anti-FANCG antibody (75-A) is an invaluable tool for researchers studying the molecular mechanisms underlying Fanconi anemia and related genomic stability disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FANCG Antibody (75-A) | sc-100740 | 100 µg/ml | $339.00 |