FAM13C1 Antibody (E-5): sc-376707
- FAM13C1 Antibody (E-5) is a mouse monoclonal IgG2b κ FAM13C1 antibody provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of FAM13C1 of mouse origin
- FAM13C1 Antibody (E-5) is recommended for detection of FAM13C1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FAM13C1 Antibody (E-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FAM13C1 Antibody (E-5) for WB applications. These reagents are now offered in bundles with FAM13C1 Antibody (E-5) (see ordering information below).
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FAM13C1 Antibody (E-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects FAM13C1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FAM13C1 (E-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FAM13C1, also known as family with sequence similarity 13, member C, consists of 585 amino acids and is part of the FAM13 family, which is implicated in various cellular processes. FAM13C1 is involved in regulating the Rho GTPase signaling pathway, which plays a crucial role in cell migration, proliferation, and differentiation. This function is particularly important in cancer biology, as dysregulation of Rho GTPases can lead to enhanced tumor cell invasion and metastasis. FAM13C1 is located on human chromosome 10, a region that harbors several critical genes, including tumor suppressor PTEN, which is associated with Cowden syndrome when mutated. Additionally, chromosome 10 is linked to various genetic disorders, highlighting FAM13C1′s significance in maintaining cellular homeostasis and potential implications in cancer research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FAM13C1 Antibody (E-5) References:
- Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21. | Troelstra, C., et al. 1992. Genomics. 12: 745-9. PMID: 1349298
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. | Grupe, A., et al. 2006. Am J Hum Genet. 78: 78-88. PMID: 16385451
- Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation. | Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
- PTEN hamartoma tumor syndromes. | Blumenthal, GM. and Dennis, PA. 2008. Eur J Hum Genet. 16: 1289-300. PMID: 18781191
- PTEN: a new guardian of the genome. | Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
- Apparent late-onset Cockayne syndrome and interstitial deletion of the long arm of chromosome 10 (del(10)(q11.23q21.2)). | Fryns, JP., et al. 1991. Am J Med Genet. 40: 343-4. PMID: 1951442
- Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome. | Laugel, V., et al. 2010. Hum Mutat. 31: 113-26. PMID: 19894250
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FAM13C1 Antibody (E-5) | sc-376707 | 200 µg/ml | $316.00 | |||
FAM13C1 Antibody (E-5): m-IgGκ BP-HRP Bundle | sc-523054 | 200 µg Ab, 40 µg BP | $354.00 | |||
FAM13C1 Antibody (E-5): m-IgG2b BP-HRP Bundle | sc-549086 | 200 µg Ab; 10 µg BP | $354.00 | |||
FAM13C1 Antibody (E-5) AC | sc-376707 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FAM13C1 Antibody (E-5) HRP | sc-376707 HRP | 200 µg/ml | $316.00 | |||
FAM13C1 Antibody (E-5) FITC | sc-376707 FITC | 200 µg/ml | $330.00 | |||
FAM13C1 Antibody (E-5) PE | sc-376707 PE | 200 µg/ml | $343.00 | |||
FAM13C1 Antibody (E-5) Alexa Fluor® 488 | sc-376707 AF488 | 200 µg/ml | $357.00 | |||
FAM13C1 Antibody (E-5) Alexa Fluor® 546 | sc-376707 AF546 | 200 µg/ml | $357.00 | |||
FAM13C1 Antibody (E-5) Alexa Fluor® 594 | sc-376707 AF594 | 200 µg/ml | $357.00 | |||
FAM13C1 Antibody (E-5) Alexa Fluor® 647 | sc-376707 AF647 | 200 µg/ml | $357.00 | |||
FAM13C1 Antibody (E-5) Alexa Fluor® 680 | sc-376707 AF680 | 200 µg/ml | $357.00 | |||
FAM13C1 Antibody (E-5) Alexa Fluor® 790 | sc-376707 AF790 | 200 µg/ml | $357.00 |