FAIM2 Antibody (H-7): sc-398737
- FAIM2 Antibody (H-7) is a mouse monoclonal IgG1 κ FAIM2 antibody provided at 200 µg/ml
- raised against amino acids 1-72 mapping at the N-terminus of FAIM2 of human origin
- FAIM2 Antibody (H-7) is recommended for detection of FAIM2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FAIM2 Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FAIM2 Antibody (H-7) for WB applications. These reagents are now offered in bundles with FAIM2 Antibody (H-7) (see ordering information below).
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FAIM2 Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects FAIM2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FAIM2 Antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FAIM2, also known as Fas apoptotic inhibitory molecule 2, LFG (Protein lifeguard), TMBIM2 (Transmembrane BAX inhibitor motif-containing protein 2), and NMP35 (neural membrane protein 35), is a 316 amino acid multipass membrane protein that plays a crucial role in protecting cells from Fas-induced apoptosis, making FAIM2 vital for cellular survival in various physiological contexts. FAIM2 is predominantly expressed in the hippocampus, where FAIM2 contributes to neuronal health and function. FAIM2 features seven transmembrane domains and shares structural similarities with Bax Inhibitor-1, another key anti-apoptotic protein. Notably, overexpression of FAIM2 leads to decreased caspase activation and reduced programmed cell death, highlighting FAIM2′s importance in regulating apoptosis specifically through binding to the FAS receptor, while FAIM2 does not confer protection against apoptosis mediated by TNF-α signaling. FAIM2′s unique properties and interactions make FAIM2 an essential target for research into apoptosis and neuroprotection.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FAIM2 Antibody (H-7) References:
- LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell death. | Somia, NV., et al. 1999. Proc Natl Acad Sci U S A. 96: 12667-72. PMID: 10535980
- Neural membrane protein 35/Lifeguard is localized at postsynaptic sites and in dendrites. | Schweitzer, B., et al. 2002. Brain Res Mol Brain Res. 107: 47-56. PMID: 12414123
- Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment. | Fernández, M., et al. 2007. J Neurochem. 103: 190-203. PMID: 17635665
- Inhibition of apoptosis by expression of antiapoptotic proteins in recombinant human keratinocytes. | Choi, CY., et al. 2007. Cell Transplant. 16: 663-74. PMID: 17912957
- The Bax Inhibitor-1 (BI-1) family in apoptosis and tumorigenesis. | Reimers, K., et al. 2008. Curr Mol Med. 8: 148-56. PMID: 18336295
- LFG: a candidate apoptosis regulatory gene family. | Hu, L., et al. 2009. Apoptosis. 14: 1255-65. PMID: 19784873
- Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system. | Schweitzer, B., et al. 1998. Mol Cell Neurosci. 11: 260-73. PMID: 9698393
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FAIM2 Antibody (H-7) | sc-398737 | 200 µg/ml | $322.00 | |||
FAIM2 Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-530908 | 200 µg Ab; 10 µg BP | $361.00 | |||
FAIM2 Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-524462 | 200 µg Ab, 40 µg BP | $361.00 | |||
FAIM2 Antibody (H-7): m-IgG1 BP-HRP Bundle | sc-544314 | 200 µg Ab; 20 µg BP | $361.00 | |||
FAIM2 Antibody (H-7) AC | sc-398737 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FAIM2 Antibody (H-7) HRP | sc-398737 HRP | 200 µg/ml | $322.00 | |||
FAIM2 Antibody (H-7) FITC | sc-398737 FITC | 200 µg/ml | $336.00 | |||
FAIM2 Antibody (H-7) PE | sc-398737 PE | 200 µg/ml | $349.00 | |||
FAIM2 Antibody (H-7) Alexa Fluor® 488 | sc-398737 AF488 | 200 µg/ml | $364.00 | |||
FAIM2 Antibody (H-7) Alexa Fluor® 546 | sc-398737 AF546 | 200 µg/ml | $364.00 | |||
FAIM2 Antibody (H-7) Alexa Fluor® 594 | sc-398737 AF594 | 200 µg/ml | $364.00 | |||
FAIM2 Antibody (H-7) Alexa Fluor® 647 | sc-398737 AF647 | 200 µg/ml | $364.00 | |||
FAIM2 Antibody (H-7) Alexa Fluor® 680 | sc-398737 AF680 | 200 µg/ml | $364.00 | |||
FAIM2 Antibody (H-7) Alexa Fluor® 790 | sc-398737 AF790 | 200 µg/ml | $364.00 |