Factor XIII A Antibody (B-8): sc-376312

Factor XIII A Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects Factor XIII A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Factor XIII A plays a crucial role in the final stages of the blood coagulation cascade, where Factor XIII A is activated to Factor XIIIa, a transglutaminase that catalyzes the cross-linking of fibrin, thereby stabilizing the fibrin clot and enhancing fibrin clot resistance to proteolytic degradation. This cross-linking is vital for maintaining hemostasis and ensuring that fibrin clots remain intact during the healing process. Factor XIII A is primarily located in the plasma and is synthesized as a heterotetramer composed of two A subunits, which possess catalytic activity, and two B subunits, which may function as carrier molecules. Factor XIII A is essential not only for effective wound healing but also for preventing excessive bleeding, making Factor XIII A a critical component in both normal physiology and pathological conditions. Anti-Factor XIII A antibody (B-8) is an invaluable tool for researchers studying coagulation processes and related disorders, providing insights into the mechanisms of clot formation and stability.

The preferred Factor XIII A antibody is Factor XIII A Antibody (A-4): sc-271122.