Factor XIII A Antibody (A-4): sc-271122

Factor XIII A Antibody (A-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects Factor XIII A in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Factor XIII A (A-4) antibody is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing versatility for different experimental needs. Factor XIII A plays a crucial role in the final stages of the coagulation cascade, where Factor XIII A catalyzes the cross-linking of fibrin, thereby stabilizing the fibrin clot and enhancing resistance to fibrinolysis. This function is vital for effective hemostasis, particularly following tissue injury, as Factor XIII A ensures that the clot remains intact long enough for tissue repair processes to occur. Factor XIII A exists in plasma as a heterotetramer composed of two A subunits and two B subunits, with the A subunits responsible for enzymatic activity. Understanding Factor XIII A structure and function is essential for elucidating Factor XIII A′s role in coagulation disorders and developing targeted therapies for conditions related to abnormal clotting.

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Factor XIII A Antibody (A-4) References:

1. Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.  |  Chambers, RC., et al. 2000. J Biol Chem. 275: 35584-91. PMID: 10952976
2. The coagulation cascade: initiation, maintenance, and regulation.  |  Davie, EW., et al. 1991. Biochemistry. 30: 10363-70. PMID: 1931959
3. The role of fibrinogen plasma levels, the -455G>A fibrinogen and the factor XIII A subunit (FXIII-A) Val34Leu polymorphism in cancer-associated venous thrombosis.  |  Tiedje, V., et al. 2011. Thromb Haemost. 106: 908-13. PMID: 21901234
4. Basic mechanisms in blood coagulation.  |  Davie, EW. and Fujikawa, K. 1975. Annu Rev Biochem. 44: 799-829. PMID: 237463
5. Activation of factor XIII is accompanied by a change in oligomerization state.  |  Anokhin, BA., et al. 2017. FEBS J. 284: 3849-3861. PMID: 28915348
6. Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation.  |  O'Hara, PJ., et al. 1987. Proc Natl Acad Sci U S A. 84: 5158-62. PMID: 3037537
7. Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas.  |  Supsrisunjai, C., et al. 2020. J Invest Dermatol. 140: 624-635.e7. PMID: 31493396
8. Cellular Factor XIII, a Transglutaminase in Human Corneal Keratocytes.  |  Orosz, ZZ., et al. 2019. Int J Mol Sci. 20: PMID: 31783511
9. The factor XIII-A Val34Leu polymorphism decreases whole blood clot mass at high fibrinogen concentrations.  |  Kattula, S., et al. 2020. J Thromb Haemost. 18: 885-894. PMID: 31989767
10. Factor XIII-A in Diseases: Role Beyond Blood Coagulation.  |  Dull, K., et al. 2021. Int J Mol Sci. 22: PMID: 33535700
11. Characterization of a cDNA coding for human factor VII.  |  Hagen, FS., et al. 1986. Proc Natl Acad Sci U S A. 83: 2412-6. PMID: 3486420
12. Intracellular factor XIII: cellular distribution of factor XIII subunit a in humans.  |  Adány, R. 1996. Semin Thromb Hemost. 22: 399-408. PMID: 8989823

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Factor XIII A Antibody (A-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Factor XIII A Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Factor XIII A Antibody (A-4) Specifications

Alternate Product Name: Factor XIII A

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 641-672

Epitope Target: Factor XIII A

Epitope Species: human

Product Reactivity/Detection: Factor XIII A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Factor XIII A Antibody (A-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin