Factor VII Antibody (RFF-VII/2): sc-59507
- Factor VII Antibody (RFF-VII/2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against purified Factor VII of human origin
- recommended for detection of Factor VII of human origin by WBIP; non cross-reactive with reduced Factor VII
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Factor VII Antibody (RFF-VII/2). This work is in progress.
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Factor VII Antibody (RFF-VII/2) is a mouse monoclonal IgG1 antibody that detects Factor VII in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Factor VII, also known as serum prothrombin conversion accelerator, proconvertin, or coagulation factor 7, is a crucial component in the hemostatic process, playing a vital role in the blood coagulation cascade. This 406 amino acid protein is synthesized in the liver and circulates as an inactive precursor until activated by proteolytic cleavage at the Arg 152-Ile 153 site, resulting in Factor VII A formation. The active form of Factor VII is a serine protease consisting of a heavy chain linked by disulfide bonds to a light chain, featuring two epidermal growth factor-like domains essential for function. These domains enable Factor VII′s interaction with other coagulation factors, facilitating prothrombin conversion to thrombin, a critical step in fibrin clot formation. Understanding Factor VII′s structure and function is essential, as deficiencies or mutations in the F7 gene can lead to bleeding disorders, although many individuals with such mutations may remain asymptomatic or exhibit mild symptoms. Anti-Factor VII antibody (RFF-VII/2) serves as an invaluable tool for researchers studying coagulation pathways and related disorders, providing insights into hemostasis mechanisms and potential therapeutic targets.
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Factor VII Antibody (RFF-VII/2) References:
- Plasma lipoproteins enhance tissue factor-independent factor VII activation. | Kjalke, M., et al. 2000. Arterioscler Thromb Vasc Biol. 20: 1835-41. PMID: 10894826
- Recombinant activated factor VII in cardiac surgery. | Herbertson, M. 2004. Blood Coagul Fibrinolysis. 15 Suppl 1: S31-2. PMID: 15166932
- Clinical phenotypes and factor VII genotype in congenital factor VII deficiency. | Mariani, G., et al. 2005. Thromb Haemost. 93: 481-7. PMID: 15735798
- Recombinant activated factor VII for hemorrhage after pediatric cardiac surgery. | Singh, SP., et al. 2012. Asian Cardiovasc Thorac Ann. 20: 19-23. PMID: 22371937
- Recombinant activated factor VII and aortic surgery. | Thompson, JF. 2013. Eur J Vasc Endovasc Surg. 45: 626. PMID: 23531347
- Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients. | van Geffen, M., et al. 2013. Thromb Res. 132: 116-22. PMID: 23731565
- Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect. | Mathijssen, NC., et al. 2013. Thromb Res. 132: 256-62. PMID: 23834817
- Novel factor VII gene mutations in six families with hereditary coagulation factor VII deficiency. | Zhang, X., et al. 2021. J Clin Lab Anal. 35: e23905. PMID: 34342048
- Binding of human factor VII and VIIa to monocytes. | Broze, GJ. 1982. J Clin Invest. 70: 526-35. PMID: 6980899
- Interaction of activated factor VII and active site-inhibited activated factor VII with tissue factor. | Sørensen, BB. and Rao, LV. 1998. Blood Coagul Fibrinolysis. 9 Suppl 1: S67-71. PMID: 9819031
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor VII Antibody (RFF-VII/2) | sc-59507 | 200 µg/ml | $322.00 |