Factor VII Activators
Factor VII activators are primarily compounds that can influence Factor VII activity indirectly by affecting coagulation or related pathways. These compounds do not directly activate Factor VII but can modulate the environment or conditions conducive to its activation.Phosphatidylserine and other phospholipids like Lysolecithin and Ethanolamine contribute to the membrane dynamics that facilitate the formation of the Factor VIIa-Tissue Factor complex, an essential step in coagulation activation.
Calcium ions are crucial for the coagulation cascade, including the function and stability of the Factor VIIa-Tissue Factor complex. Arachidonic acid, Collagen, Thrombin, ADP, Epinephrine, and Serotonin, all play roles in platelet function, vascular injury response, or the coagulation cascade, which can indirectly influence Factor VII activity. Inhibitors of Tissue Factor Pathway Inhibitor (TFPI), which regulates the activity of the Factor VIIa-Tissue Factor complex, might also indirectly enhance Factor VII activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phosphatidyl-L-serine | 51446-62-9 | sc-507548 | 10 g | $46.00 | ||
Phosphatidylserine, exposed on activated platelet surfaces, can enhance the formation of the Factor VIIa-Tissue Factor complex, indirectly increasing FVII activity. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions are essential for coagulation cascade activation and can indirectly promote Factor VII activation by stabilizing the Factor VIIa-Tissue Factor complex. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin, a critical enzyme in the coagulation cascade, can cleave and activate factor VII directly, although this mechanism is less common compared to tissue factor-mediated activation. | ||||||
Ethanolamine | 141-43-5 | sc-203042 sc-203042A sc-203042B | 25 ml 500 ml 2.5 L | $22.00 $56.00 $204.00 | 1 | |
Ethanolamine, a component of phospholipids, might contribute to membrane dynamics influencing coagulation factors including Factor VII. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid, released during platelet activation, can influence clot formation and potentially enhance Factor VII activation. | ||||||
Collagen IV | sc-29010 | 1 mg | $224.00 | 11 | ||
Collagen, exposed during vascular injury, can initiate platelet activation and aggregation, indirectly enhancing Factor VII activity. | ||||||
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $79.00 $184.00 $348.00 $942.00 $4688.00 $9370.00 | 1 | |
ADP, released by activated platelets, plays a role in platelet aggregation and could indirectly influence Factor VII activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, which promotes platelet aggregation, could indirectly enhance Factor VII activation in the coagulation cascade. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin, released from activated platelets, can influence coagulation and might indirectly affect Factor VII activity. | ||||||