Factor V Antibody (GMA-044): sc-65945

Factor V Antibody (GMA-044) is a mouse monoclonal IgG1 antibody that detects Factor V in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Factor V, also known as proaccelerin or labile factor, is a crucial 2,196 amino acid glycoprotein that plays a pivotal role in the blood coagulation cascade. Upon tissue injury, Factor V is cleaved by thrombin to form an active, calcium-dependent dimer, which is essential for the formation of the prothrombinase complex alongside catalytic Factor Xa and calcium ions on the surface of platelets or endothelial cells. This complex is responsible for the conversion of prothrombin into active thrombin, a key step in the coagulation process that leads to the formation of fibrin clots and platelet aggregation. Factor V also serves as a cofactor for activated protein C, which plays a critical role in regulating coagulation by selectively degrading Factor Va and Factor Xa, thus preventing excessive clotting. Given this dual role in coagulation and anticoagulation, any alterations at the Factor V locus can significantly impact hemostatic balance, leading to conditions such as hemorrhagic diathesis or thrombosis. Anti-Factor V antibody (GMA-044) is an invaluable tool for researchers studying these complex mechanisms in human physiology and pathology.

The preferred Factor V antibody is Factor V Antibody (6A5): sc-13512.