Factor V Antibody (AHV-5110): sc-73458

Factor V Antibody (AHV-5110) is a mouse monoclonal IgG1 antibody that detects Factor V in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Factor V, also known as proaccelerin or labile factor, is a crucial 2,196 amino acid glycoprotein that plays a pivotal role in the blood coagulation cascade. Upon tissue injury, Factor V is cleaved by thrombin to form an active, calcium-dependent dimer, which is essential for the formation of the prothrombinase complex alongside catalytic Factor Xa and calcium ions on the surface of platelets or endothelial cells. This complex is responsible for the conversion of prothrombin into active thrombin, a key step in hemostasis. The importance of Factor V extends beyond its procoagulant function; Factor V also serves as a cofactor for activated protein C, which regulates coagulation by selectively degrading Factor Va and Factor Xa, thus preventing excessive clotting. Given Factor V′s dual role in coagulation and anticoagulation, mutations or alterations in the Factor V gene can lead to significant clinical conditions, including hemorrhagic diathesis or thrombosis, making the study of this protein vital for understanding and managing blood disorders. Anti-Factor V antibody (AHV-5110) is an invaluable tool for researchers investigating the complexities of coagulation and its associated pathologies.

The preferred Factor V antibody is Factor V Antibody (6A5): sc-13512.