Factor H Antibody (H-7): sc-166613
- Factor H Antibody (H-7) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 61-360 mapping within an internal region of Factor H of human origin
- Anti-Factor H Antibody (H-7) is recommended for detection of Factor H of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Factor H Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Factor H Antibody (H-7) for WB applications. This reagent is now offered in a bundle with Factor H Antibody (H-7) (see ordering information below).
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Factor H Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Factor H in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Factor H (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Factor H plays a crucial role in regulating the alternative complement pathway, which is essential for the immune response and helps prevent damage to host tissues during inflammation. Factor H is a serum glycoprotein composed of 1213 amino acids, organized into 20 short consensus repeats (SCRs) that facilitate diverse functions, including acting as a cofactor for Factor I, which inactivates C3b. Additionally, Factor H interacts with various cellular receptors and glycosaminoglycans, highlighting importance beyond the complement system. Notably, Factor H deficiencies are linked to acute renal diseases, underscoring significance in maintaining kidney health and overall immune regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Factor H Antibody (H-7) References:
- Factor H as a regulator of the classical pathway activation. | Kishore, U. and Sim, RB. 2012. Immunobiology. 217: 162-8. PMID: 21852018
- Complement factor H-ligand interactions: self-association, multivalency and dissociation constants. | Perkins, SJ., et al. 2012. Immunobiology. 217: 281-97. PMID: 22137027
- Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells. | Weinberger, AW., et al. 2014. Ophthalmic Res. 51: 59-66. PMID: 24280833
- CD55, CD59, factor H and factor H-like 1 gene expression analysis in tumors of the ovary and corpus uteri origin. | Kapka-Skrzypczak, L., et al. 2015. Immunol Lett. 167: 67-71. PMID: 26261870
- Annexin A2 Enhances Complement Activation by Inhibiting Factor H. | Renner, B., et al. 2016. J Immunol. 196: 1355-65. PMID: 26729803
- Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. | Calippe, B., et al. 2017. Immunity. 46: 261-272. PMID: 28228282
- Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy. | Tortajada, A., et al. 2017. Kidney Int. 92: 953-963. PMID: 28637589
- Upregulation of Complement Factor H by SOCS-1/3⁻STAT4 in Lung Cancer. | Yoon, YH., et al. 2019. Cancers (Basel). 11: PMID: 30987235
- Contact activation-induced complex formation between complement factor H and coagulation factor XIIa. | Thangaraj, SS., et al. 2020. J Thromb Haemost. 18: 876-884. PMID: 31984663
- Complement-Independent Modulation of Influenza A Virus Infection by Factor H. | Murugaiah, V., et al. 2020. Front Immunol. 11: 355. PMID: 32269562
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor H Antibody (H-7) | sc-166613 | 200 µg/ml | $316.00 | |||
Factor H Antibody (H-7): m-IgG1 BP-HRP Bundle | sc-531681 | 200 µg Ab; 20 µg BP | $354.00 | |||
Factor H Antibody (H-7) AC | sc-166613 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Factor H Antibody (H-7) HRP | sc-166613 HRP | 200 µg/ml | $316.00 | |||
Factor H Antibody (H-7) FITC | sc-166613 FITC | 200 µg/ml | $330.00 | |||
Factor H Antibody (H-7) PE | sc-166613 PE | 200 µg/ml | $343.00 | |||
Factor H Antibody (H-7) Alexa Fluor® 488 | sc-166613 AF488 | 200 µg/ml | $357.00 | |||
Factor H Antibody (H-7) Alexa Fluor® 546 | sc-166613 AF546 | 200 µg/ml | $357.00 | |||
Factor H Antibody (H-7) Alexa Fluor® 594 | sc-166613 AF594 | 200 µg/ml | $357.00 | |||
Factor H Antibody (H-7) Alexa Fluor® 647 | sc-166613 AF647 | 200 µg/ml | $357.00 | |||
Factor H Antibody (H-7) Alexa Fluor® 680 | sc-166613 AF680 | 200 µg/ml | $357.00 | |||
Factor H Antibody (H-7) Alexa Fluor® 790 | sc-166613 AF790 | 200 µg/ml | $357.00 |