Factor B Antibody (9B6): sc-57506
- Factor B Antibody (9B6) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against Factor B of human origin
- recommended for detection of Factor B of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Factor B Antibody (9B6). This work is in progress.
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Factor B Antibody (9B6) is a mouse monoclonal IgG1 antibody that detects Factor B in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Factor B plays a crucial role in the alternative pathway of the complement system, where Factor D cleaves Factor B into two fragments, Ba and Bb. The Bb fragment combines with complement Factor 3b to form the C3 or C5 convertase, which is essential for amplifying the complement response. This process is vital for the differentiation and proliferation of preactivated B lymphocytes, as well as for the lysis of erythrocytes and stimulation of lymphocyte blastogenesis. Ba serves an important regulatory function by inhibiting the proliferation of preactivated B lymphocytes, thereby maintaining immune homeostasis. The intricate balance of these interactions underscores Factor B′s importance in immune responses and potential implications in various diseases, including autoimmune disorders and infections. Factor B (9B6) antibody serves as an invaluable tool for researchers exploring the complexities of the complement system and its role in human health and disease.
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Factor B Antibody (9B6) References:
- Conformational changes during the assembly of factor B from its domains by (1)H NMR spectroscopy and molecular modelling: their relevance to the regulation of factor B activity. | Hinshelwood, J. and Perkins, SJ. 2000. J Mol Biol. 301: 1267-85. PMID: 10966820
- Factor B activation in systemic lupus erythematosus. | Segurado, OG., et al. 1990. Arthritis Rheum. 33: 1598-9. PMID: 2222545
- Deficiency in complement factor B. | Slade, C., et al. 2013. N Engl J Med. 369: 1667-9. PMID: 24152280
- AICAR suppresses TNF-α-induced complement factor B in RPE cells. | Chung, EJ., et al. 2017. Sci Rep. 7: 17651. PMID: 29247196
- Complement factor B/C2 in molluscs regulates agglutination and illuminates evolution of the Bf/C2 family. | Peng, M., et al. 2019. FASEB J. 33: 13323-13333. PMID: 31550175
- Mechanism of ribosome rescue by alternative ribosome-rescue factor B. | Chan, KH., et al. 2020. Nat Commun. 11: 4106. PMID: 32796827
- The molecular genetics and polymorphism of C2 and factor B. | Campbell, RD. 1987. Br Med Bull. 43: 37-49. PMID: 3315100
- A Novel Case of Complement Factor B Deficiency. | Gauthier, A., et al. 2021. J Clin Immunol. 41: 277-279. PMID: 33165708
- Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer. | Shimazaki, R., et al. 2021. Cell Oncol (Dordr). 44: 937-950. PMID: 34075561
- The prognostic value of plasma complement factor B (CFB) in thyroid carcinoma. | Wu, P., et al. 2021. Bioengineered. 12: 12854-12866. PMID: 34898340
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor B Antibody (9B6) | sc-57506 | 100 µg/ml | $322.00 |