Factor B Antibody (28A3): sc-69772
- Factor B Antibody (28A3) is a mouse monoclonal IgG1 provided at 100 µl
- raised against purified Factor B of human origin
- recommended for detection of Factor B of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Factor B Antibody (28A3). This work is in progress.
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Factor B Antibody (28A3) is a mouse monoclonal IgG1 antibody that detects Factor B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Factor B plays a crucial role in the alternative pathway of the complement system, where Factor D cleaves Factor B into two fragments, Ba and Bb. The Bb fragment is essential for forming the C3 and C5 convertases, which are pivotal in amplifying the complement response and facilitating the lysis of pathogens. Additionally, Factor B is involved in the differentiation and proliferation of preactivated B lymphocytes, which are vital for adaptive immunity. The Ba fragment has been shown to inhibit the proliferation of these B lymphocytes, highlighting the regulatory balance that Factor B maintains within the immune system. Understanding Factor B function is important not only for its role in immune responses but also for its implications in various diseases, including autoimmune disorders and infections. Anti-Factor B antibody (28A3) is an invaluable tool for researchers studying the complement system and its impact on human health.
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Factor B Antibody (28A3) References:
- Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. | Makinen, T., et al. 1999. J Biol Chem. 274: 21217-22. PMID: 10409677
- Factor B structure provides insights into activation of the central protease of the complement system. | Milder, FJ., et al. 2007. Nat Struct Mol Biol. 14: 224-8. PMID: 17310251
- Platelet-derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury. | Tuuminen, R., et al. 2016. Transplantation. 100: 303-13. PMID: 26371596
- Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis. | Fleury, OM., et al. 2017. Infect Immun. 85: PMID: 28373353
- Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome. | Coan, PM., et al. 2017. Hypertension. 70: 624-33. PMID: 28739975
- Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement. | Farries, TC., et al. 1988. Biochem J. 253: 667-75. PMID: 3140783
- Scaffold attachment factor B: distribution and interaction with ERα in the rat brain. | Hashimoto, T., et al. 2020. Histochem Cell Biol. 153: 323-338. PMID: 32086573
- Identification of intermolecular bonds between human factor B and Cobra Venom Factor important for C3 convertase stability. | Hew, BE., et al. 2020. Toxicon. 184: 68-77. PMID: 32526239
- Defective microbial sensing and clearance in perianal Crohn's disease: a role for complement factor B. | Ghate, A. and Uhlig, HH. 2023. Gut. 72: 2010-2012. PMID: 37098439
- Hypocomplementemia of membranoproliferative nephritis. Dependence of the nephritic factor reaction on properdin factor B. | Ruley, EJ., et al. 1973. J Clin Invest. 52: 896-904. PMID: 4693654
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor B Antibody (28A3) | sc-69772 | 100 µl | $322.00 |