Ezrin Antibody (6A84): sc-71082

Ezrin Antibody (6A84) is a mouse monoclonal IgG1 antibody that detects Ezrin in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Ezrin is a crucial member of the ERM (Ezrin, Radixin, Moesin) protein family, which plays a vital role in linking the cytoskeleton to the plasma membrane, thereby influencing cell shape, motility, and signaling. Ezrin is primarily localized beneath the plasma membrane, where Ezrin facilitates the interaction between cytoskeletal components and membrane proteins, which is essential for maintaining cellular integrity and facilitating communication between the cell′s internal and external environments. Notably, Ezrin acts as a substrate for various protein-tyrosine kinases, including the epidermal growth factor receptor, highlighting Ezrin′s importance in signal transduction pathways that regulate cell growth and differentiation. Additionally, Ezrin has been identified as an A-kinase anchoring protein (AKAP78), which underscores Ezrin′s role in spatially organizing signaling complexes within the cell. The unique phosphorylation patterns exhibited by Ezrin, in contrast to its homologs Moesin and Radixin, further emphasize Ezrin′s specific regulatory functions in different cellular contexts. With versatile applications and critical role in cellular dynamics, anti-Ezrin antibody (6A84) is an invaluable tool for researchers studying cytoskeletal organization and signaling pathways.

The preferred Ezrin antibody is Ezrin Antibody (3C12): sc-58758.