Ezrin Antibody (6A84): sc-71082
- Ezrin Antibody (6A84) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 362-585 of Ezrin of human origin
- recommended for detection of Ezrin of mouse, rat, human and bovine origin by WB, IP, IF and IHC(P)
- See Ezrin (3C12): sc-58758 for Ezrin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Ezrin Antibody (6A84) for WB and IHC(P) applications. These reagents are now offered in bundles with Ezrin Antibody (6A84) (see ordering information below).
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Ezrin Antibody (6A84) is a mouse monoclonal IgG1 antibody that detects Ezrin in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Ezrin is a crucial member of the ERM (Ezrin, Radixin, Moesin) protein family, which plays a vital role in linking the cytoskeleton to the plasma membrane, thereby influencing cell shape, motility, and signaling. Ezrin is primarily localized beneath the plasma membrane, where Ezrin facilitates the interaction between cytoskeletal components and membrane proteins, which is essential for maintaining cellular integrity and facilitating communication between the cell′s internal and external environments. Notably, Ezrin acts as a substrate for various protein-tyrosine kinases, including the epidermal growth factor receptor, highlighting Ezrin′s importance in signal transduction pathways that regulate cell growth and differentiation. Additionally, Ezrin has been identified as an A-kinase anchoring protein (AKAP78), which underscores Ezrin′s role in spatially organizing signaling complexes within the cell. The unique phosphorylation patterns exhibited by Ezrin, in contrast to its homologs Moesin and Radixin, further emphasize Ezrin′s specific regulatory functions in different cellular contexts. With versatile applications and critical role in cellular dynamics, anti-Ezrin antibody (6A84) is an invaluable tool for researchers studying cytoskeletal organization and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ezrin Antibody (6A84) References:
- Ezrin protein overexpression predicts the poor prognosis of pancreatic ductal adenocarcinomas. | Piao, J., et al. 2015. Exp Mol Pathol. 98: 1-6. PMID: 25445504
- Ezrin regulates skin fibroblast size/mechanical properties and YAP-dependent proliferation. | Quan, C., et al. 2018. J Cell Commun Signal. 12: 549-560. PMID: 28889372
- Role of Ezrin Phosphorylation in HIV-1 Replication. | Kamiyama, H., et al. 2018. Front Microbiol. 9: 1912. PMID: 30210460
- Ezrin Promotes Stem Cell Properties in Pancreatic Ductal Adenocarcinoma. | Penchev, VR., et al. 2019. Mol Cancer Res. 17: 929-936. PMID: 30655325
- Ezrin promotes hepatocellular carcinoma progression by modulating glycolytic reprogramming. | Wang, X., et al. 2020. Cancer Sci. 111: 4061-4074. PMID: 32639665
- Ezrin regulates synovial angiogenesis in rheumatoid arthritis through YAP and Akt signalling. | Chen, Q., et al. 2021. J Cell Mol Med. 25: 9378-9389. PMID: 34459110
- The interaction of ATP11C-b with ezrin contributes to its polarized localization. | Inoue, H., et al. 2021. J Cell Sci. 134: PMID: 34528675
- Hypoxia and Ezrin Expression in Primary Melanoma Have High Prognostic Relevance. | Maccio, U., et al. 2022. Int J Mol Sci. 23: PMID: 36142656
- Ezrin and Its Phosphorylated Thr567 Form Are Key Regulators of Human Extravillous Trophoblast Motility and Invasion. | Tabrizi, MEA., et al. 2023. Cells. 12: PMID: 36899847
- Inhibition of ezrin phosphorylation by NSC305787 attenuates procaterol-stimulated ciliary beating in airway cilia. | Kawaguchi, K., et al. 2024. Biochem Biophys Res Commun. 703: 149685. PMID: 38373381
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ezrin Antibody (6A84) | sc-71082 | 200 µg/ml | $322.00 | |||
Ezrin Antibody (6A84): m-IgG Fc BP-HRP Bundle | sc-539346 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ezrin Antibody (6A84): m-IgG1 BP-HRP Bundle | sc-541427 | 200 µg Ab; 20 µg BP | $361.00 |