Ezrin Antibody (5G110): sc-71081

Ezrin Antibody (5G110) is a mouse monoclonal IgG1 antibody that detects Ezrin in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Ezrin is a crucial member of the ERM (Ezrin, Radixin, Moesin) protein family, which plays a vital role in linking the cytoskeleton to the plasma membrane, thereby facilitating cellular processes such as cell signaling, adhesion, and motility. Ezrin is predominantly localized beneath the plasma membrane, where anti-Ezrin antibody (5G110) recognizes scaffold interactions with various signaling molecules, including protein-tyrosine kinases and phosphatases, which are essential for regulating cellular responses to external stimuli. Notably, Ezrin serves as a significant substrate for several protein-tyrosine kinases, including the epidermal growth factor receptor, highlighting Ezrin′s importance in signal transduction pathways that govern cell growth and differentiation. Additionally, Ezrin functions as an A-kinase anchoring protein (AKAP78), which is critical for the spatial and temporal regulation of cAMP-dependent signaling. The unique phosphorylation patterns exhibited by Ezrin, in contrast to Moesin and Radixin homologs, further underscore Ezrin′s specific regulatory roles in various cellular contexts. With Ezrin′s ability to interact with a range of proteins and involvement in key cellular functions, Ezrin monoclonal antibody (5G110) serves as an essential tool for research in cell biology and disease mechanisms.

The preferred Ezrin antibody is Ezrin Antibody (3C12): sc-58758.