Ezrin Antibody (4i251): sc-71080

Ezrin Antibody (4i251) is a mouse monoclonal IgG1 antibody that detects Ezrin in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Ezrin is a crucial member of the ERM (Ezrin, Radixin, Moesin) protein family, which plays a vital role in linking the cytoskeleton to the plasma membrane, thereby facilitating cellular processes such as cell signaling, adhesion, and migration. Ezrin is predominantly localized beneath the plasma membrane, where Ezrin acts as a scaffold that organizes membrane proteins and cytoskeletal elements, which is essential for maintaining cell shape and structure. Notably, Ezrin is a significant substrate for various protein-tyrosine kinases, including the epidermal growth factor receptor, highlighting Ezrin′s involvement in signaling pathways that regulate cell growth and differentiation. Additionally, Ezrin functions as an anchoring protein for cAMP-dependent protein kinase, known as AKAP78, which underscores Ezrin′s role in spatially organizing signaling complexes within the cell. The distinct phosphorylation patterns exhibited by Ezrin, Moesin, and Radixin, despite their high homology, suggest that these proteins may have specialized functions in different cellular contexts, making anti-Ezrin antibody (4i251) an invaluable tool for researchers studying the dynamics of cell membrane interactions and cytoskeletal organization.

The preferred Ezrin antibody is Ezrin Antibody (3C12): sc-58758.