Exportin T Antibody (LOS1): sc-136203

Exportin T Antibody (LOS1) is a mouse monoclonal IgG1 antibody that detects Exportin T in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Exportin T plays a crucial role as a nuclear export receptor for tRNA, selectively exporting mature tRNA that has been correctly processed at both the 5′ and 3′ ends, which is essential for proper protein synthesis and cellular function. The TpsiC loop within mature tRNA is vital for the selection process, ensuring that only correctly folded tRNA molecules are transported out of the nucleus. Exportin T forms a nuclear export complex in a RanGTP-dependent manner, facilitating bidirectional shuttling through nuclear pore complexes. The efficiency of Exportin T is significantly enhanced by interactions with various nucleoporins, which help to localize both empty and tRNA-bound Exportin T near the nuclear pore complexes, thereby optimizing the export process. The gene encoding human Exportin T is located on chromosome 12, highlighting evolutionary conservation and importance across species. Anti-Exportin T antibody (LOS1) is an invaluable tool for researchers studying tRNA export mechanisms and their implications in cellular biology.

The preferred Exportin T antibody is Exportin T Antibody (D-11): sc-514591.