Exportin 5 Antibody (A-11): sc-271036

Exportin 5 Antibody (A-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects Exportin 5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Exportin 5 antibody (A-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Exportin 5, also known as Exp5, plays a crucial role in nuclear export of RNA molecules, specifically recognizing and transporting RNAs that contain minihelix motifs. These motifs are essential for proper export of small RNAs, as they consist of a double-stranded stem and a protruding single-stranded tail, which are critical for stability and functionality of RNA during transport. By facilitating export of these RNA species, Exportin 5 ensures availability in cytoplasm for translation and other cellular processes, thereby influencing gene expression and cellular function. Additionally, Exportin 5 is involved in transport of various proteins between nucleus and cytoplasm, highlighting importance in maintaining cellular homeostasis and regulating gene expression.

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Exportin 5 Antibody (A-11) References:

1. Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.  |  Brownawell, AM. and Macara, IG. 2002. J Cell Biol. 156: 53-64. PMID: 11777942
2. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.  |  Bohnsack, MT., et al. 2002. EMBO J. 21: 6205-15. PMID: 12426392
3. Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA.  |  Calado, A., et al. 2002. EMBO J. 21: 6216-24. PMID: 12426393
4. Exportin-5 mediates nuclear export of minihelix-containing RNAs.  |  Gwizdek, C., et al. 2003. J Biol Chem. 278: 5505-8. PMID: 12509441
5. Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3.  |  Gwizdek, C., et al. 2004. J Biol Chem. 279: 884-91. PMID: 14570900
6. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.  |  Yi, R., et al. 2003. Genes Dev. 17: 3011-6. PMID: 14681208
7. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs.  |  Bohnsack, MT., et al. 2004. RNA. 10: 185-91. PMID: 14730017
8. The brain-specific double-stranded RNA-binding protein Staufen2: nucleolar accumulation and isoform-specific exportin-5-dependent export.  |  Macchi, P., et al. 2004. J Biol Chem. 279: 31440-4. PMID: 15166236
9. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.  |  Chen, T., et al. 2004. Mol Cell Biol. 24: 6608-19. PMID: 15254228
10. Exportin-5 Functions as an Oncogene and a Potential Therapeutic Target in Colorectal Cancer.  |  Shigeyasu, K., et al. 2017. Clin Cancer Res. 23: 1312-1322. PMID: 27553833
11. The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.  |  Duman, G., et al. 2022. Endokrynol Pol. 73: 8-15. PMID: 34855193
12. Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5.  |  Chen, X., et al. 2022. ACS Chem Biol. 17: 3450-3457. PMID: 36475596

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Exportin 5 Antibody (A-11) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Exportin 5 Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Exportin 5 Antibody (A-11) Specifications

Alternate Product Name: Exportin 5

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 905-1204

Epitope Target: Exportin 5

Epitope Species: human

Product Reactivity/Detection: Exportin 5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Exportin 5 Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin