EXOSC9 Antibody (D-6): sc-271815
- EXOSC9 Antibody (D-6) is a mouse monoclonal IgG1 κ EXOSC9 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of EXOSC9 of human origin
- EXOSC9 Antibody (D-6) is recommended for detection of EXOSC9 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-EXOSC9 Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for EXOSC9 Antibody (D-6) for WB applications. These reagents are now offered in bundles with EXOSC9 Antibody (D-6) (see ordering information below).
EXOSC9 Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects EXOSC9 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EXOSC9 (D-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EXOSC9, also known as exosome component 9, plays a crucial role in the exosome complex, which is essential for degrading unstable mRNAs, particularly those containing AU-rich elements in their untranslated regions. This process maintains cellular homeostasis and regulates gene expression by preventing potentially harmful mRNA accumulation. EXOSC9 functions in both nucleus and cytoplasm as a ribonuclease facilitating mRNA decay without contributing to exosome complex stability. EXOSC9 can act independently of the exosome, demonstrating dual functionality in cellular processes. EXOSC9 undergoes proteolytic cleavage during apoptosis and has been linked to autoimmune diseases like myositis and scleroderma. Four isoforms of EXOSC9 exist due to alternative splicing, contributing to diverse functional roles in cellular regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EXOSC9 Antibody (D-6) References:
- The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. | Mukherjee, D., et al. 2002. EMBO J. 21: 165-74. PMID: 11782436
- Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. | Brouwer, R., et al. 2002. Arthritis Res. 4: 134-8. PMID: 11879549
- Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. | Raijmakers, R., et al. 2002. J Mol Biol. 323: 653-63. PMID: 12419256
- The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. | Raijmakers, R., et al. 2003. J Biol Chem. 278: 30698-704. PMID: 12788944
- PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. | Raijmakers, R., et al. 2004. Arthritis Rheum. 50: 565-9. PMID: 14872500
- Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen. | Mahler, M., et al. 2005. Arthritis Res Ther. 7: R704-13. PMID: 15899056
- Identification of differentially expressed transcripts in bovine rumen and abomasum using a differential display method. | Roh, SG., et al. 2007. J Anim Sci. 85: 395-403. PMID: 17235024
- Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis. | Schilders, G., et al. 2007. Arthritis Res Ther. 9: R12. PMID: 17280603
- Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. | van Dijk, EL., et al. 2007. RNA. 13: 1027-35. PMID: 17545563
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EXOSC9 Antibody (D-6) | sc-271815 | 200 µg/ml | $322.00 | |||
EXOSC9 Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-527294 | 200 µg Ab; 10 µg BP | $361.00 | |||
EXOSC9 Antibody (D-6): m-IgG1 BP-HRP Bundle | sc-532667 | 200 µg Ab; 20 µg BP | $361.00 | |||
EXOSC9 Antibody (D-6) AC | sc-271815 AC | 500 µg/ml, 25% agarose | $424.00 | |||
EXOSC9 Antibody (D-6) HRP | sc-271815 HRP | 200 µg/ml | $322.00 | |||
EXOSC9 Antibody (D-6) FITC | sc-271815 FITC | 200 µg/ml | $336.00 | |||
EXOSC9 Antibody (D-6) PE | sc-271815 PE | 200 µg/ml | $349.00 | |||
EXOSC9 Antibody (D-6) Alexa Fluor® 488 | sc-271815 AF488 | 200 µg/ml | $364.00 | |||
EXOSC9 Antibody (D-6) Alexa Fluor® 546 | sc-271815 AF546 | 200 µg/ml | $364.00 | |||
EXOSC9 Antibody (D-6) Alexa Fluor® 594 | sc-271815 AF594 | 200 µg/ml | $364.00 | |||
EXOSC9 Antibody (D-6) Alexa Fluor® 647 | sc-271815 AF647 | 200 µg/ml | $364.00 | |||
EXOSC9 Antibody (D-6) Alexa Fluor® 680 | sc-271815 AF680 | 200 µg/ml | $364.00 | |||
EXOSC9 Antibody (D-6) Alexa Fluor® 790 | sc-271815 AF790 | 200 µg/ml | $364.00 |