EXOSC8 Antibody (H-8): sc-393027
- EXOSC8 Antibody (H-8) is a mouse monoclonal IgG1 κ EXOSC8 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 135-276 mapping at the C-terminus of EXOSC8 of human origin
- EXOSC8 Antibody (H-8) is recommended for detection of EXOSC8 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-EXOSC8 Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for EXOSC8 Antibody (H-8) for WB applications. These reagents are now offered in bundles with EXOSC8 Antibody (H-8) (see ordering information below).
EXOSC8 Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects EXOSC8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EXOSC8 (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EXOSC8, also known as exosome component 8, plays a crucial role in RNA metabolism as a component of the exosome complex, which is essential for degrading unstable mRNAs containing AU-rich elements in untranslated regions. EXOSC8 is localized primarily in the nucleolus and is one of six RNase-PH domain subunits forming a PNPase-like ring structure within the exosome, vital for processing 7S pre-RNA. EXOSC8′s structural integrity facilitates proper assembly and function of the exosome complex, ensuring efficient RNA turnover and regulation of gene expression. EXOSC8 interacts with various proteins, enhancing RNA processing and stability roles, and can self-interact, indicating potential involvement in complex regulatory networks within the cell.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EXOSC8 Antibody (H-8) References:
- AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. | Chen, CY., et al. 2001. Cell. 107: 451-64. PMID: 11719186
- A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. | Jiang, T. and Altman, S. 2002. Proc Natl Acad Sci U S A. 99: 5295-300. PMID: 11929972
- Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. | Raijmakers, R., et al. 2002. J Mol Biol. 323: 653-63. PMID: 12419256
- A protein interaction framework for human mRNA degradation. | Lehner, B. and Sanderson, CM. 2004. Genome Res. 14: 1315-23. PMID: 15231747
- Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. | Anderson, JR., et al. 2006. RNA. 12: 1810-6. PMID: 16912217
- Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. | Williams, JM., et al. 1998. Mol Microbiol. 27: 171-86. PMID: 9466265
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EXOSC8 Antibody (H-8) | sc-393027 | 200 µg/ml | $322.00 | |||
EXOSC8 Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-530336 | 200 µg Ab; 10 µg BP | $361.00 | |||
EXOSC8 Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-523779 | 200 µg Ab, 40 µg BP | $361.00 | |||
EXOSC8 Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-543997 | 200 µg Ab; 20 µg BP | $361.00 | |||
EXOSC8 Antibody (H-8) AC | sc-393027 AC | 500 µg/ml, 25% agarose | $424.00 | |||
EXOSC8 Antibody (H-8) HRP | sc-393027 HRP | 200 µg/ml | $322.00 | |||
EXOSC8 Antibody (H-8) FITC | sc-393027 FITC | 200 µg/ml | $336.00 | |||
EXOSC8 Antibody (H-8) PE | sc-393027 PE | 200 µg/ml | $349.00 | |||
EXOSC8 Antibody (H-8) Alexa Fluor® 488 | sc-393027 AF488 | 200 µg/ml | $364.00 | |||
EXOSC8 Antibody (H-8) Alexa Fluor® 546 | sc-393027 AF546 | 200 µg/ml | $364.00 | |||
EXOSC8 Antibody (H-8) Alexa Fluor® 594 | sc-393027 AF594 | 200 µg/ml | $364.00 | |||
EXOSC8 Antibody (H-8) Alexa Fluor® 647 | sc-393027 AF647 | 200 µg/ml | $364.00 | |||
EXOSC8 Antibody (H-8) Alexa Fluor® 680 | sc-393027 AF680 | 200 µg/ml | $364.00 | |||
EXOSC8 Antibody (H-8) Alexa Fluor® 790 | sc-393027 AF790 | 200 µg/ml | $364.00 |