EXOSC3 Antibody (B-8): sc-166568
- EXOSC3 Antibody (B-8) is a mouse monoclonal IgG1 κ EXOSC3 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1-275 representing full length EXOSC3 of human origin
- EXOSC3 Antibody (B-8) is recommended for detection of EXOSC3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-EXOSC3 Antibody (B-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for EXOSC3 Antibody (B-8) for WB applications. This reagent is now offered in a bundle with EXOSC3 Antibody (B-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
EXOSC3 Antibody (B-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects EXOSC3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EXOSC3 (B-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EXOSC3, also known as p10, CGI-102, RRP40, or hRrp40p, is a crucial component of the exosome complex, which is responsible for degrading unstable mRNAs, particularly those containing AU-rich elements in their untranslated regions. EXOSC3 is primarily located in the cytoplasm and nucleolus, where EXOSC3 plays a vital role in RNA processing and stability. EXOSC3 contains a putative S1 RNA-binding domain, enabling RNA binding effectively, and is essential for the structural integrity of the exosome complex. EXOSC3 is involved in processing 7S pre-RNA into mature 5.8S ribosomal RNA, highlighting EXOSC3′s importance in ribosome biogenesis and overall cellular function. EXOSC3′s ability to interact with various RNA substrates underscores EXOSC3′s significance in maintaining RNA homeostasis within the cell, making anti-EXOSC3 antibody (B-8) an invaluable tool for researchers studying RNA metabolism and related cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EXOSC3 Antibody (B-8) References:
- The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. | Allmang, C., et al. 1999. Genes Dev. 13: 2148-58. PMID: 10465791
- Three novel components of the human exosome. | Brouwer, R., et al. 2001. J Biol Chem. 276: 6177-84. PMID: 11110791
- Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. | Brouwer, R., et al. 2002. Arthritis Res. 4: 134-8. PMID: 11879549
- Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. | Raijmakers, R., et al. 2002. J Mol Biol. 323: 653-63. PMID: 12419256
- A view to a kill: structure of the RNA exosome. | Shen, V. and Kiledjian, M. 2006. Cell. 127: 1093-5. PMID: 17174886
- Localization of AU-rich element-containing mRNA in cytoplasmic granules containing exosome subunits. | Lin, WJ., et al. 2007. J Biol Chem. 282: 19958-68. PMID: 17470429
- Identification of genes upregulated by recombinant interferon-alpha in HepG2 cells by suppressive subtractive hybridization analysis. | Qu, JH., et al. 2007. Hepatobiliary Pancreat Dis Int. 6: 290-3. PMID: 17548253
- Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing. | Wang, HW., et al. 2007. Proc Natl Acad Sci U S A. 104: 16844-9. PMID: 17942686
- EXOSC3 mutations in pontocerebellar hypoplasia type 1: novel mutations and genotype-phenotype correlations. | Eggens, VR., et al. 2014. Orphanet J Rare Dis. 9: 23. PMID: 24524299
- Novel EXOSC3 mutation causes complicated hereditary spastic paraplegia. | Halevy, A., et al. 2014. J Neurol. 261: 2165-9. PMID: 25149867
- Novel EXOSC3 pathogenic variant results in a mild course of neurologic disease with cerebellum involvement. | Le Duc, D., et al. 2020. Eur J Med Genet. 63: 103649. PMID: 30986545
- Homozygous EXOSC3 c.395A>C Variants in Pontocerebellar Hypoplasia Type 1B: A Sibling Pair With Childhood Lethal Presentation and Literature Review. | Szeto, CH., et al. 2023. Cureus. 15: e39226. PMID: 37337484
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EXOSC3 Antibody (B-8) | sc-166568 | 200 µg/ml | $322.00 | |||
EXOSC3 Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-521658 | 200 µg Ab, 40 µg BP | $361.00 | |||
EXOSC3 Antibody (B-8) AC | sc-166568 AC | 500 µg/ml, 25% agarose | $424.00 | |||
EXOSC3 Antibody (B-8) HRP | sc-166568 HRP | 200 µg/ml | $322.00 | |||
EXOSC3 Antibody (B-8) FITC | sc-166568 FITC | 200 µg/ml | $336.00 | |||
EXOSC3 Antibody (B-8) PE | sc-166568 PE | 200 µg/ml | $349.00 | |||
EXOSC3 Antibody (B-8) Alexa Fluor® 488 | sc-166568 AF488 | 200 µg/ml | $364.00 | |||
EXOSC3 Antibody (B-8) Alexa Fluor® 546 | sc-166568 AF546 | 200 µg/ml | $364.00 | |||
EXOSC3 Antibody (B-8) Alexa Fluor® 594 | sc-166568 AF594 | 200 µg/ml | $364.00 | |||
EXOSC3 Antibody (B-8) Alexa Fluor® 647 | sc-166568 AF647 | 200 µg/ml | $364.00 | |||
EXOSC3 Antibody (B-8) Alexa Fluor® 680 | sc-166568 AF680 | 200 µg/ml | $364.00 | |||
EXOSC3 Antibody (B-8) Alexa Fluor® 790 | sc-166568 AF790 | 200 µg/ml | $364.00 |