Exo84 Antibody (H-1): sc-515532
- Exo84 Antibody (H-1) is a mouse monoclonal IgG1 κ Exo84 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 564-725 mapping near the C-terminus of Exo84 of human origin
- Exo84 Antibody (H-1) is recommended for detection of Exo84 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Exo84 Antibody (H-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Exo84 Antibody (H-1) for WB applications. These reagents are now offered in bundles with Exo84 Antibody (H-1) (see ordering information below).
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Exo84 Antibody (H-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Exo84 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Exo84 antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Exo84, also known as Exocyst complex 84 kDa subunit, plays a pivotal role in the exocyst complex, which is essential for the proper targeting of exocytic vesicles to specific docking sites on the plasma membrane. This complex is crucial for exocytosis, a process that facilitates the secretion of hormones and neurotransmitters, as well as the incorporation of membrane proteins and lipids into the plasma membrane, thereby influencing cell-cell communication, growth, and polarity. Exo84 interacts with other components of the exocyst complex, including Sec3, Sec5, Sec6, Sec8, Sec10, and Sec15, and is regulated by active Ral GTPases, which are vital for modulating the activities of the exocyst complex. Understanding the function and interactions of Exo84 is important for elucidating the mechanisms underlying membrane trafficking and cellular signaling, making Exo84 (H-1) monoclonal antibody a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Exo84 Antibody (H-1) References:
- Exo84p is an exocyst protein essential for secretion. | Guo, W., et al. 1999. J Biol Chem. 274: 23558-64. PMID: 10438536
- Ral GTPases regulate exocyst assembly through dual subunit interactions. | Moskalenko, S., et al. 2003. J Biol Chem. 278: 51743-8. PMID: 14525976
- The exocyst complex in polarized exocytosis. | Hsu, SC., et al. 2004. Int Rev Cytol. 233: 243-65. PMID: 15037366
- The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization. | Wang, S., et al. 2004. J Biol Chem. 279: 35958-66. PMID: 15205466
- Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. | Jin, R., et al. 2005. EMBO J. 24: 2064-74. PMID: 15920473
- The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif. | Dong, G., et al. 2005. Nat Struct Mol Biol. 12: 1094-100. PMID: 16249794
- RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC. | Lalli, G. 2009. J Cell Sci. 122: 1499-506. PMID: 19383721
- Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. | Issaq, SH., et al. 2010. Mol Cancer Res. 8: 223-31. PMID: 20145037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Exo84 Antibody (H-1) | sc-515532 | 200 µg/ml | $316.00 | |||
Exo84 Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-531400 | 200 µg Ab; 10 µg BP | $354.00 | |||
Exo84 Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-525083 | 200 µg Ab, 40 µg BP | $354.00 | |||
Exo84 Antibody (H-1): m-IgG1 BP-HRP Bundle | sc-544531 | 200 µg Ab; 20 µg BP | $354.00 | |||
Exo84 Antibody (H-1) AC | sc-515532 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Exo84 Antibody (H-1) HRP | sc-515532 HRP | 200 µg/ml | $316.00 | |||
Exo84 Antibody (H-1) FITC | sc-515532 FITC | 200 µg/ml | $330.00 | |||
Exo84 Antibody (H-1) PE | sc-515532 PE | 200 µg/ml | $343.00 | |||
Exo84 Antibody (H-1) Alexa Fluor® 488 | sc-515532 AF488 | 200 µg/ml | $357.00 | |||
Exo84 Antibody (H-1) Alexa Fluor® 546 | sc-515532 AF546 | 200 µg/ml | $357.00 | |||
Exo84 Antibody (H-1) Alexa Fluor® 594 | sc-515532 AF594 | 200 µg/ml | $357.00 | |||
Exo84 Antibody (H-1) Alexa Fluor® 647 | sc-515532 AF647 | 200 µg/ml | $357.00 | |||
Exo84 Antibody (H-1) Alexa Fluor® 680 | sc-515532 AF680 | 200 µg/ml | $357.00 | |||
Exo84 Antibody (H-1) Alexa Fluor® 790 | sc-515532 AF790 | 200 µg/ml | $357.00 |