EVC Antibody (H-1): sc-271955

EVC Antibody (H-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects EVC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-EVC antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EVC protein, associated with Ellis-van Creveld syndrome, plays a crucial role in the hedgehog signaling pathway, which is essential for proper embryonic development and tissue patterning. EVC protein is primarily located in the intracellular space, particularly in developing ribs, heart, kidney, and lung tissues, where EVC protein contributes to the normal formation of facial structures, limbs, teeth, and nails. Mutations in the EVC gene can disrupt these processes, leading to significant developmental disorders such as short-limb dwarfism, ectodermal dysplasia, and various cardiac anomalies, including irregularities in atrioventricular septum development. Furthermore, the EVC gene has been linked to Weyers acrodental dysostosis, an autosomal dominant condition characterized by distinct facial abnormalities and limb defects, underscoring the importance of EVC in both skeletal and organ development.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

EVC Antibody (H-1) References:

1. Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis.  |  Ruiz-Perez, VL., et al. 2000. Nat Genet. 24: 283-6. PMID: 10700184
2. A new gene, EVC2, is mutated in Ellis-van Creveld syndrome.  |  Galdzicka, M., et al. 2002. Mol Genet Metab. 77: 291-5. PMID: 12468274
3. Unusual pattern of inheritance and orodental changes in the Ellis-van Creveld syndrome.  |  Mostafa, MI., et al. 2005. Genet Couns. 16: 75-83. PMID: 15844783
4. Ellis-van Creveld syndrome and dyserythropoiesis.  |  Scurlock, D., et al. 2005. Arch Pathol Lab Med. 129: 680-2. PMID: 15859642
5. [From gene to disease; EVC, EVC2, and Ellis-van Creveld syndrome].  |  van Hagen, JM., et al. 2005. Ned Tijdschr Geneeskd. 149: 929-31. PMID: 15884406
6. A novel heterozygous deletion in the EVC2 gene causes Weyers acrofacial dysostosis.  |  Ye, X., et al. 2006. Hum Genet. 119: 199-205. PMID: 16404586
7. Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.  |  Ruiz-Perez, VL., et al. 2007. Development. 134: 2903-12. PMID: 17660199
8. The gene for the Ellis-van Creveld syndrome is located on chromosome 4p16.  |  Polymeropoulos, MH., et al. 1996. Genomics. 35: 1-5. PMID: 8661097

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EVC Antibody (H-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-EVC Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EVC Antibody (H-1) Specifications

Alternate Product Name: EVC

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 181-480

Epitope Target: EVC

Epitope Species: human

Product Reactivity/Detection: EVC

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for EVC Antibody (H-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin