ETFB Antibody (E-10): sc-514901

ETFB Antibody (E-10) is a mouse monoclonal IgG1 antibody that detects ETFB (electron transfer flavoprotein subunit beta) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ETFB is a 255 amino acid protein that plays a crucial role in cellular metabolism by acting as a shuttle for electrons, transferring them between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. This function is vital for the efficient conversion of fatty acids, amino acids, and choline into energy, highlighting its importance in metabolic pathways. Localized primarily in the mitochondrion matrix, ETFB is abundantly expressed in the liver, heart, and skeletal muscle, with lower levels found in the brain, placenta, lung, kidney, and pancreas. ETFB exists as a heterodimer composed of alpha and beta subunits, utilizing flavin adenine dinucleotide (FAD) as a cofactor and binding one adenosine monophosphate (AMP) per subunit. The gene encoding ETFB is located on human chromosome 19q13.33 and mouse chromosome 7 B4, and mutations in this gene have been associated with glutaric aciduria type 2B (GA2B), an autosomal recessive disorder affecting fatty acid, amino acid, and choline metabolism. ETFB (E-10) antibody is an essential tool for researchers studying metabolic disorders and mitochondrial function.

The preferred ETFB antibody is ETFB Antibody (F-1): sc-514807.