ESET Antibody (A-7): sc-271553
- ESET Antibody (A-7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of ESET of human origin
- recommended for detection of ESET of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-271553 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ESET Antibody (A-7) for WB applications. These reagents are now offered in bundles with ESET Antibody (A-7) (see ordering information below).
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ESET Antibody (A-7) is a mouse monoclonal IgG1 antibody that detects ERG-associated protein with SET domain (ESET) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ESET is a crucial nuclear protein belonging to the histone-lysine methyltransferase family, specifically the Suvar3-9 subfamily, and plays a significant role in regulating chromatin structure. This highly conserved protein, consisting of 150 amino acids, methylates Lys-9 of histone H3, a modification serving as an epigenetic marker for transcriptional repression. Such methylation recruits heterochromatin protein 1 (HP1) to methylated histones, influencing gene expression and maintaining genomic stability. ESET shows predominant expression in testis, with SETDB1 gene located on chromosome 1q21, and mutations can lead to loss of methyltransferase activity, underscoring ESET′s critical role in cellular function and development. Anti-ESET antibody (A-7) serves as an essential tool for researchers studying epigenetic regulation and chromatin dynamics in various biological contexts.
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ESET Antibody (A-7) References:
- Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation. | Lee, J., et al. 2008. Hum Mol Genet. 17: 1774-82. PMID: 18319327
- ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage. | Yeap, LS., et al. 2009. Epigenetics Chromatin. 2: 12. PMID: 19811652
- Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. | Matsui, T., et al. 2010. Nature. 464: 927-31. PMID: 20164836
- Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation. | Hong, W., et al. 2011. Biochem Biophys Res Commun. 415: 650-5. PMID: 22079090
- De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET. | Rowe, HM., et al. 2013. Development. 140: 519-29. PMID: 23293284
- ESET histone methyltransferase regulates osteoblastic differentiation of mesenchymal stem cells during postnatal bone development. | Lawson, KA., et al. 2013. FEBS Lett. 587: 3961-7. PMID: 24188826
- ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription. | Hwang, YJ., et al. 2014. Nucleic Acids Res. 42: 1628-43. PMID: 24234436
- The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice. | An, J., et al. 2014. Cell Death Dis. 5: e1196. PMID: 24763053
- A Histone Methyltransferase ESET Is Critical for T Cell Development. | Takikita, S., et al. 2016. J Immunol. 197: 2269-79. PMID: 27511731
- Epigenetic inhibition of lncRNA GMDS-AS1 by methyltransferase ESET promoted cell viability and metastasis of hepatocellular carcinoma. | Huang, J., et al. 2023. Clin Transl Oncol. 25: 1793-1804. PMID: 36737533
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ESET Antibody (A-7) | sc-271553 | 200 µg/ml | $322.00 | |||
ESET Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-537661 | 200 µg Ab; 10 µg BP | $361.00 | |||
ESET Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-534995 | 200 µg Ab; 40 µg BP | $361.00 | |||
ESET Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-545290 | 200 µg Ab; 20 µg BP | $361.00 | |||
ESET Antibody (A-7) X | sc-271553 X | 200 µg/0.1 ml | $322.00 |