ERRα Antibody (2ERR37): sc-65722

ERRα Antibody (2ERR37) is a mouse monoclonal IgG1 antibody that detects ERRα in human samples through western blotting (WB) and immunoprecipitation (IP) applications. ERRα, or Estrogen Related Receptor Alpha, is a crucial nuclear receptor that belongs to the superfamily of ligand-regulated transcription factors and is part of the NR3B orphan nuclear receptor subgroup. ERRα is primarily located in the nucleus, where anti-ERRα antibody (2ERR37) plays a significant role in modulating the estrogen signaling pathway, which is vital for various physiological processes. Nuclear localization of ERRα is essential as ERRα (2ERR37) antibody directly influences gene expression related to mitochondrial biogenesis and oxidative metabolism, thereby impacting energy homeostasis and metabolic regulation. ERRα expression increases during fasting and cold exposure, highlighting ERRα′s importance in adaptive responses to environmental changes. Studies have shown that mice lacking ERRα struggle to maintain body temperature in cold conditions, underscoring ERRα′s role in thermoregulation. ERRα is implicated in the maintenance and formation of cartilage, making ERRα (2ERR37) monoclonal antibody a potential target for therapeutic interventions in joint-related diseases. ERRα Antibody (2ERR37) is an invaluable tool for researchers investigating the multifaceted roles of ERRα in health and disease.

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ERRα Antibody (2ERR37) References:

1. Nuclear receptor ERRα contributes to castration-resistant growth of prostate cancer via its regulation of intratumoral androgen biosynthesis.  |  Xu, Z., et al. 2020. Theranostics. 10: 4201-4216. PMID: 32226548
2. ERRα expression in ovarian cancer and promotes ovarian cancer cells migration in vitro.  |  Huang, W., et al. 2022. Arch Gynecol Obstet. 305: 1525-1534. PMID: 34797420
3. Estrogen-related Receptor α (ERRα) Functions in The Hypoxic Injury of Microglial Cells.  |  Deng, CY., et al. 2022. J Vet Res. 66: 131-140. PMID: 35582481
4. Estrogen Related Receptor Alpha (ERRα) a Bridge between Metabolism and Adrenocortical Cancer Progression.  |  Avena, P., et al. 2022. Cancers (Basel). 14: PMID: 36010877
5. Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency.  |  Dufour, CR., et al. 2022. Commun Biol. 5: 955. PMID: 36097051
6. HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis.  |  Sannigrahi, MK., et al. 2022. JCI Insight. 7: PMID: 36134662
7. New insights into cholesterol-mediated ERRα activation in breast cancer progression and pro-tumoral microenvironment orchestration.  |  Brindisi, M., et al. 2023. FEBS J. 290: 1481-1501. PMID: 36237175
8. Estrogen-Related Receptor Alpha (ERRα) Promotes Cancer Stem Cell-Like Characteristics in Breast Cancer.  |  Muduli, K., et al. 2023. Stem Cell Rev Rep. 19: 2807-2819. PMID: 37584854
9. SUMO-specific protease 2 regulates lipid droplet size through ERRα-mediated CIDEA expression in adipocytes.  |  Lee, JS., et al. 2023. Biochem Biophys Res Commun. 681: 29-35. PMID: 37748256
10. Silencing of ERRα gene represses cell proliferation and induces apoptosis in human skin fibroblasts.  |  Nanashima, N., et al. 2025. Mol Med Rep. 31: PMID: 39450559

The preferred ERRα antibody is ERRα Antibody (2ERR7): sc-65720.